2-Chloro-3,5-dimethoxy-6-methoxy carbonyl

It was claimed that cyclization of ethyl 2-chloro-5-cyclopropyl-6- [(7V-(4,5-dimethoxy-2-nitrophenyl)methoxy)carbonyl]-A-(2-fluoro-3-hydroxy-l-oxo-2-propen-l-yl)amino nicotinate (321) in boiling aqueous dioxane in the presence of K2C03 overnight yielded l- [(4,5-dimethoxy-2-nitrophe-nyl)methoxy]carbonyl -9-cyclopropyl-3-fluoro-2-oxo-2,6-dihydropyrido[l, 2-u]pyrimidine-7-carboxylate (160) (95MIP1, 96MIP4, 96USP5580872). 

S (Z)]]-7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptanoic acid cjs-4-amino-5-chloro-N-[l-[3-(p-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-o-anisamide cis-4-amino-5-chloro-N-[l-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenz amide [l-amino-3-[[[2-[(diaminomethylene)amino]-4-thiazolyljmethyl] thio]propylidene]sulfamide 2-amino- l,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one l-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-l,4-benzodioxin-2-yl)carbonyl]piperazine... 

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