Information, chemical substance

European Chemical Substances Information System (ESIS)... 

Under section 10 authority, EPA has a Chemical Substances Information Network (CSIN) prototype under test by industry, academia, unions and state government offices. The system is intended to permit easier access to existing data resources. 

Information management by EPA, as mandated under TSCA has centered on the development of CSIN (Chemical Substances Information Network). In response to Section 10(b) this information management system has evolved to retrieve toxicological and other scientific data which could be useful to the Administrator in carrying out the act. After several years and about an equal number of millions of dollars, currently a prototype networking... 

One particular area of this response is the management of information required by TSCA. Monsanto Company s C. Elmer and J.R. Condray itemized these requirements, and reviewed the status and implications of each. Some unanticipated benefits derived from the mandated burden were emphasized. EPA s requirements for information are not yet complete further growth is expected. While EPA s Chemical Substances Information Network (CSIN) is recognized as valid in concept, there is concern that its scope may be expanding that originally envisioned for information submitted to EPA under TSCA. In addition, attention must be given to the identification and maintenance of the reliability level of the information reported, stored and extracted for use under TSCA. 

CAS Registry Number (CASRN) This unique identifier is assigned by the American Chemical Society to chemicals recorded in the CAS Registry System. This number is used to access various chemical databases including the Hazardous Substances Data Bank (HSDB), CAS Online, Chemical Substances Information Network, and many others. This entry is also useful to conclusively identify a substance regardless of the assigned name. 

This paper addresses the computer-based algorithms that support the handling of chemical substance information. Since the methods used to represent information about chemical substances are critical to the nature of the algorithms used, a variety of chemical substance representation systems are presented, along with the various system processes necessary to handle computer-based files of chemical substance information. 

CA Registry File CAS Orbit (dictionary), Dialog (dictionary), Questel (dictionary and structure), STN dictionary and structure) chemical substance information and identification... 

REACH introduces a single system covering both existing and new substances under the old system and categorises substances as either non-phase-in substances (i.e. those not produced or marketed prior to the entry into force of REACH) or phase-in substances (those listed in the European Inventory of Existing Commercial chemical Substances Information System - EINECS, or those that have been manufactured in the Community, but not placed on the Community market, in the last fifteen years). 

Chemical Substances Information Network (CSIN) The Toxic Substances Control Act (TSCA), upon passage in 1976, became part of a complex array of at least 12 pieces of federal legislation concerned with chemicals and their mixtures. This legislation requires the private and public sectors to collect and analyze data and information relevant to the development, use smd disposal of chemical substances. An analysis conducted by EPA identified several hundred information resources that these sectors were using when responding to these needs. It became obvious that a new approach was needed to reduce the burden on organizations for the identification, acquisition and processing of material relevant to chemical substances. 

A further version of the Specinfo database is also available through STN where the mass spectra along with other spectroscopic and chemical substance information can be found through the usual CAS type search options as weU as single peak data such as base peak, base peak intensity, nominal mass, peak position etc. The 9th September 1999 upgrade reported over 65,900 mass spectra stored. For more details see http //www.cas.org/ONLINE/DBSS/specinfoss.html. 

Because the program is still under development, final decisions have not been made as to the content, type, and structure of the data bases to be developed. Preliminary information indicates that the implementation strategy is to develop a network of on-line information systems concerning chemical substances. This network, called Chemical Substances Information Network (CSIN), will have seven subsystems ... 

MITRE Report No. 7558. Chemical Substances Information Network (Volumes I and II), June 1977. EPA Office of Toxic Substances The Chemical Substances Information Network by the Public Liaison Subcommittee of the Interagency Toxic Substances Data Committee, April, 1979. Toxic Substances Strategy Committee. A Report to the President Toxic Chemicals and Public Protection, May, 1980. 

The most authoritative collection of disclosed chemical substance information, containing more than 48 million organic and inorganic substances and 61 million... 

The lECSC, which as noted above originated in December 1994, is periodically updated to include new chemical substances. Information on the number of substances on the Inventory over time, and specifically at the time the Provisions took effect in 2003, is difficult to find. As of 2007, it reportedly contained "over 45,000" substances [141]. By 2010, the lECSC contain 45,602 chemical substances in total, including 3,166 confidential substances [142]. 

ESIS European chemical Substances Information System provides information about the risks and safety of chemical compounds http //esis.jrc.ec.europa.eu/... 

EC IHCP. (2009). ESIS European chemical substances information system Retrieved 4/10/09, from http //ecb.jrc.ec.europa.eu/esis/. 

Nomenclature systems developed from the need to organize chemical substance information for printed works. In the case of CAS, the driving force was the preparation of the Chemical Substance Indexes, while for lUPAC the need was somewhat less specific but in keeping with the broad communication needs of the international chemical community. Of the two systems, CAS is the more up-to-date as it is used in the publication (both in print and electronically) of the volume Chemical Substance Indexes and the five-year Collective Indexes (see Chemical Abstracts Service Information System). The lUPAC system is somewhat less quick to respond to changing nomenclature needs as the process for approval of new rules is an international cooperative effort. 

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