Channel voltage

Inwardly Rectifying K+ Channels Voltage-dependent Na+ Channels... [Pg.13]

Voltage-dependent Na+ Channels Voltage-dependent Ca2+ Channels (3-Adrenergic System Cardiac Glycosides... [Pg.101]

Ionotropic Glutamate Receptors Voltage-dependent Ca2+ Channels Voltage-gated K+ Channels... [Pg.130]

Inwardly Rectifying K+ Channels ATP-dependent K+ Channels Voltage-dependent Ca2+ Channels Ryanodine Receptor Voltage-dependent Na2+ Channels... [Pg.347]

L-type calcium channels (voltage-gated calcium channels L-subtype) Similarity to Diltiazem and a second ligand. ZINC db ( 50 K commercially available subset screened but most filtered to achieve desired PK profile using VolSurf). SHOP similarity, and feature-presence filtering down to 36 compounds 7 hits 18 tested, active in a vasorelaxant assay and some had novel structures. [67]... [Pg.96]

Rudy, B. and McBain, C. J. Kv3 channels voltage-gated K+ channels designed for high-frequency repetitive firing. Trends Neurosci. 24 517-526,2001. [Pg.264]

We have found that the communication between Ca2+ sparks and BK channels can be tuned by membrane potential (this study, Herrera et al 2001) and by the accessory / subunit (Brenner et al 2000, Petkov et al 2001). This effect can be accounted for based on the allosteric relationship between the BK channel voltage and Ca2+ sensors, whereby membrane potential depolarization favours a channel conformation that has a higher Ca2+ sensitivity. The /b subunit has a similar role to increase the apparent Ca2+ sensitivity of the a subunit. [Pg.201]

Keywords CS-syndrome Neurotransmitter release Pyrethroids T-syndrome Voltage-gated calcium channels Voltage-gated sodium channels... [Pg.49]

Bean BP (1989) Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 340 153-6... [Pg.65]

Transmitter-gated ion channel Voltage-activated Na+ channel Voltage-activated Ca + channel... [Pg.484]

Voltage-gated sodium channel Voltage-gated calcium channel... [Pg.752]

McGivern, J.G. and J.F. Worley. 2007. Ion channels Voltage gated. In Comprehensive Medicinal Chemistry, Triggle, D.J. and Taylor, J.B., Eds. Elsevier Oxford. [Pg.81]

Starace, D. M., Selvin, P. R., and Bezanilla, F. (2002). Resonance energy transfer measurements of transmembrane motion in the Shaker K+ channel voltage sensing region. Biophys.J. 82, 174a. [Pg.241]

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