Voltage gated potassium channels

Kv 3 -subunits are auxiliary subunits of Shaker-related Kv-channels, which belong to the Kvl subfamily of voltage-gated potassium channels. Kv(3 -subunits may function as chaperones in Kva -subunit assembly and may modulate the gating properties of Kv-channels. In particular, some Kv(3 -subunits may confer a rapid inactivation to otherwise non-inactivating Kv-channels. [Pg.677]

Kv-channel is an abbreviation of voltage-gated potassium channels. K stands for potassium and v for voltage. [Pg.677]

Shaker-channels, eag (ether- -go-go)-channels, slo (slow-poke)-channels were cloned from behavioral Drosophila melanogaster mutants. The channels were named according to the Drosophila mutant phenotype, Shaker, ether-go-go, slow-poke. Subsequently, eag-cDNA was used to clone related voltage-gated potassium channel subunits erg (eag-related) and elk (eag-like). The human erg ortholog (HERG) mediates cardiac DCS. [Pg.1131]

Pongs O (1999) Voltage-gated potassium channels from hyperexcitability to excitement. FEBS Lett 452 31-35... [Pg.1312]

Peukert S, Brendel J, Pirard B, Briiggemann A, Below P, Kleemann HW, Hem-merle H, Schmidt W. Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kvl.5. J Med Chem 2003 46 486-98. [Pg.422]

Gulbins, E., Szabo, I., Baltzer, K. and Eang, E, 1997, Ceramide-induced inhibition ofT lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases. Proc. Natl. Acad. Sci. USA 94 7661-7666... [Pg.242]

Treptow, W., Marrink, S.J., Tarek, M. Gating motions in voltage-gated potassium channels revealed by coarse-grained molecular dynamics simulations. J. Phys. Chem. B 2008, 112, 3277-82. [Pg.18]

Monticelli, L., Robertson, K.M., MacCallum, J.L., Tieleman, D.P. Computer simulation of the KvAP voltage-gated potassium channel steered molecular dynamics of the voltage sensor. FEBS Lett. 2004, 564, 325-32. [Pg.20]

Retigabine is a novel anticonvulsant drug in development (Phase II). It activates voltage-gated potassium channels and also affects GABA neurotransmission in the GABAyi receptor. ... [Pg.305]

Yellen, G. (2002) The voltage-gated potassium channels and their relatives. Nature 419, 35-42. [Pg.418]

Kim, E., Day, T.A., Bennett, J.L. and Pax, R.A. (1 995a) Cloning and functional expression of a Shaker-related voltage-gated potassium channel gene from Schistosoma mansoni (Trematoda Digenea). Parasitology 110, 1 71-180. [Pg.383]

Pozo-Rosich P, Clover L, Saiz A, Vincent A, Graus F. Voltage-gated potassium channel antibodies in limbic encephalitis. Ann Neurol 2003 54(4) 530-533. [Pg.174]

Viallard JF, Vincent A, Moreau JF, Parrens M, Pellegrin JL, Ellie E. Thymoma-associated neuromyotonia with antibodies against voltage-gated potassium channels presenting as chronic intestinal pseudo-obstruction. Eur Neurol 2005 53(2) 60-63. [Pg.179]

Hirano K, Kuratani K, Fujiyoshi M et al. (2006) Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice. Neuropharmacology 413(2) 159—162... [Pg.51]

Pardo LA (2004) Voltage-gated potassium channels in cell proliferation. Physiology (Bethesda) 19 285-292... [Pg.86]

Preussat K, Beetz C, Schrey M, Kraft R, Wolfl S, Kalff R, Patt S (2003) Expression of voltage-gated potassium channels Kvl.3 and Kvl.5 in human gliomas. Neurosci Lett 346 33-36... [Pg.87]

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