Voltage-gated potassium channel Kvl

Peukert S, Brendel J, Pirard B, Briiggemann A, Below P, Kleemann HW, Hem-merle H, Schmidt W. Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kvl.5. J Med Chem 2003 46 486-98. 

Preussat K, Beetz C, Schrey M, Kraft R, Wolfl S, Kalff R, Patt S (2003) Expression of voltage-gated potassium channels Kvl.3 and Kvl.5 in human gliomas. Neurosci Lett 346 33-36... 

Two new classes of voltage-gated potassium channel Kvl.3 blockers were obtained by transformations of naturally occurring lAellinone <04JMC2327>. 

Goetz, M. A., Hensens, O. D., Zink, D. L., Bet al. (1998) Potent nor-triterpenoid blockers of the voltage-gated potassium channel Kvl.3 from spachea correae. Tetrahedron Lett. 39, 2895-2898. 

Felix, J. P., Bugianesi, R. M., Schmalhofer, W. A., et al. (1999) Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kvl.3. Biochemistry 38,4922-4930. 

Archer SL, London B, Hampl y Wu X, Nsair A, Puttagunta L, Hashimoto K, Waite RE, Michelakis ED. Impairment of h poxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kvl.5. FASEB J 2001 15 1801-1803. 

Kv 3 -subunits are auxiliary subunits of Shaker-related Kv-channels, which belong to the Kvl subfamily of voltage-gated potassium channels. Kv(3 -subunits may function as chaperones in Kva -subunit assembly and may modulate the gating properties of Kv-channels. In particular, some Kv(3 -subunits may confer a rapid inactivation to otherwise non-inactivating Kv-channels. 

Voltage-gated potassium channels also have a number of different binding sites. Similar to sodium channels, there is a binding site for peptide toxins at the outer vestibule of the pore. This binding site has been identified by site-directed mutagenesis for different peptide toxins, e.g., for the toxin ShK from a sea anemone, which blocks Kvl.3, or for Charybdotoxin, which blocks various potassium channels [19, 20],... 

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