Modulation of voltage-gated ion channels

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Metabotropic receptors can modulate voltage-gated ion channels directly (membrane-delimited action) and also by the formation of diffusible second messengers through G protein-mediated effects on enzymes involved in their synthesis. A classic example of the latter type of action is provided by the beta-adrenoceptor, which generates cAMP via the activation of adenylyl cyclase. The answer is (B). 

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