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Sodium channel voltage-gated

Catterall WA (2000) From ionic currents to molecular mechanisms the structure and function of voltage-gated sodium channels. Neuron 26 13-25... [Pg.1308]

Catterall WA, Goldin AL, Waxman SG (2005) International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev 57 397-409. [Pg.1308]

Schultz, J., Hoffmuller, U., Krause, G., Ashurst, J., Macias, M. J., Schmieder, P., Schneider-Mergener, J., and Oschknat, H. (1998). Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels. Nat. Struct. Biol. 5, 19-24. [Pg.122]

Yang, N. B., George, A. L. Jr. and Horn, R. Molecular basis of charge movement in voltage-gated sodium channels. Neuron 16,113-122,1996. [Pg.109]

Many antiseizure drugs act on voltage-gated sodium channels to limit high-frequency but not low-frequency firing of neurons 634... [Pg.629]

Wood, J. N. and Baker, M. Voltage-gated sodium channels. Curr. Opin. Pharmacol. 1 17-21, 2001. [Pg.937]

Carbamazepine may act primarily by inhibition of voltage-gated sodium channels. [Pg.602]

Keywords CS-syndrome Neurotransmitter release Pyrethroids T-syndrome Voltage-gated calcium channels Voltage-gated sodium channels... [Pg.49]

There have been many studies over the last 40 years that provide substantial evidence that voltage-gated sodium channels in the CNS are major sites of action for the pyrethroids in mammals [1, 20-25]. This literature has been recently critically reviewed by Soderlund [10] from the viewpoint of the neurotoxic action of pyrethroids in mammals and we will rely heavily on this review in our summary below. [Pg.55]

Using both voltage- and patch-clamp electrophysiological protocols, pyrethroids have been shown to affect the kinetic properties of voltage-gated sodium channels in a way that is consistent with their neuroexcitability [22], With voltage-clamp,... [Pg.55]

Recent results that examined the effect of pyrethroids on voltage-gated sodium channels expressed in human embryonic kidney (HEK293) cells grown in... [Pg.57]

Tan J, Soderlund DM (2009) Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin. Neurotoxicology... [Pg.69]

Tan J, Soderlund DM (2011) Independent and joint modulation of rat Nav1.6 voltage-gated sodium channels by coexpression with the auxiliary betal and beta2 subunits. Biochem Biophys Res Commun 407 788-792... [Pg.69]

O Reilly AO, Khambay BP, Williamson MS, Field LM, Wallace BA, Davies TG (2006) Modelling insecticide-binding sites in the voltage-gated sodium channel. Biochem J 396 255-263... [Pg.70]

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