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Voltage gated calcium channels subunits

Table 1 Comparison of the physiological, pharmacological, and electrophysiological characteristics of voltage-gated calcium channel subunit subtypes... [Pg.47]

High-affinity ligand to the a2S-1 subunit of voltage-gated calcium channel... [Pg.753]

Pharmacology Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in CNS tissues. Although the... [Pg.1256]

Arikkath, J. and Campbell, K.P. (2003) Auxiliary subunits essential components of the voltage-gated calcium channel complex. Current Opinion in Neurobiology 13, 298-307. [Pg.278]

Dolphin, A.C. (2003) P subunits of voltage-gated calcium channels. Journal of Bioenergetics and Biomembranes 35, 599-620. [Pg.279]

Arikkath J, Campbell KP (2003) Auxiliary subunits essential components of the voltage-gated calcium channel complex. Curr Opin Neurobiol 13 298-307 Amot MI, Stotz SC, Jarvis SE, Zamponi GW (2000) Differential modulation of N-type IB and P/Q-type 1A calcium channels by different G protein subunit isoforms. J Physiol 527 Pt 2 203-12... [Pg.64]

The dihydropyridine- (DHP)-sensitive calcium channel purified from skeletal muscle is composed of five subunits al9 a2, P, y, and 8 (9-12). The cty subunit (molecular weight Mr 170 kD) forms a functional voltage-gated calcium channel (9, 13-15) and contains the binding sites for the three classes of calcium channel modulators 1,4-dihydropyridines (16), phenylal-kylamines, and benzothiazepines (17). The primary structure of the ax subunit was first elucidated from skeletal muscle (18) highly homologous sequences have since been cloned from cardiac muscle (13, 19, 20) and brain (21), aorta (22), and lung (23) tissue. [Pg.330]

Angelotti, T. and Hofmann, F. (1996) Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha2/delta subunit. FEES Letters, 397 331-337. [Pg.180]

Van Petegem F, Clark KA, Chatelain FC, Minor DL Jr. Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature 2004 429(6992) 671-5. [Pg.142]

QinN, Yagel S, Momplaisir ML, CoddEE,D Andrea MR. Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)deltaA subunit. Mol Pharmacol 2002 62(3) 485-96. [Pg.147]

J., et al. 2004. Identification and synthesis of [l,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the a(2)5-l subunit of voltage gated calcium channel. Bioorganic and Medicinal Chemistry Letters 14(10) 2463-2467. [Pg.41]

Voltage-gated calcium channels are complex proteins which mainly consist of four subunits aj, tt2, (3, and 5, while in skeletal muscles there is an additional y-unit which explains why CCBs do not antagonise the calcium channel in skeletal muscles. [Pg.216]

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See also in sourсe #XX -- [ Pg.49 , Pg.50 , Pg.57 , Pg.62 ]



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Calcium channels

Channel voltage

Gate voltage

Gated channels

Subunit channeling

Voltage calcium channels

Voltage-gated

Voltage-gated calcium channels

Voltage-gated channels

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