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Pyrethroids voltage-gated sodium channels

Cyfluthrin Flucythrinate Permethrin Pyrethroid Voltage-gated sodium channel [32]... [Pg.80]

Keywords CS-syndrome Neurotransmitter release Pyrethroids T-syndrome Voltage-gated calcium channels Voltage-gated sodium channels... [Pg.49]

There have been many studies over the last 40 years that provide substantial evidence that voltage-gated sodium channels in the CNS are major sites of action for the pyrethroids in mammals [1, 20-25]. This literature has been recently critically reviewed by Soderlund [10] from the viewpoint of the neurotoxic action of pyrethroids in mammals and we will rely heavily on this review in our summary below. [Pg.55]

Using both voltage- and patch-clamp electrophysiological protocols, pyrethroids have been shown to affect the kinetic properties of voltage-gated sodium channels in a way that is consistent with their neuroexcitability [22], With voltage-clamp,... [Pg.55]

Recent results that examined the effect of pyrethroids on voltage-gated sodium channels expressed in human embryonic kidney (HEK293) cells grown in... [Pg.57]

Tan J, Soderlund DM (2009) Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin. Neurotoxicology... [Pg.69]

Pyrethroid insecticides. The natural pyrethrins, which act on the voltage-gated sodium channel, are highly potent insecticides obtained from flowers of the chrysanthemum plant. Though the pyrethrins are highly active insecticides, they are not stable enough for commercial use. However, a number of structural modifications of the early pyrethrin molecule resulted in a wide range of stable commercially useful pyrethroid insectides. [Pg.131]

Deltamethrin (Decis ) Pyrethroid Cyfluthrin (Baythroid ) Pyrethroid Deltamethrin Pyrethroid Prochloraz Imidazole Voltage-gated sodium channel Voltage-gated sodium channel Voltage-gated sodium channel Cytochrome P-450 [49]... [Pg.80]

Mix deltamethrin- prochloraz Imidacloprid Pyrethroid and imidazole ChloronicotinyP Voltage-gated sodium channel and cytochrome P-450 Nicotinic acetylcholine receptor [48]... [Pg.80]

The organophosphates and carbamates as inhibitors of acetylcholinesterase (IRAC MoA Group lA and IB) still form the largest group of insecticides, followed by the pyrethroids, known to act on voltage-gated sodium channels. These classes are briefly covered below in terms of their mode of action and biological value. [Pg.766]

One of the most important chemical classes of insecticides are the pyrethroids, which act as ligands of voltage-gated sodium channels in nerve axons [8, 9]. In... [Pg.766]

Pyrethroids target voltage-gated sodium channels in the nerve axons, and behavioral effects can be attributed to a disruption in the organization of the peripheral sensory system. The spatial repellency of pyrethroids is believed to be caused by high knockdown activity and intrinsic sublethal effects, which disrupt the orientation to the natural host and/or inhibit feeding. " ... [Pg.105]

See other pages where Pyrethroids voltage-gated sodium channels is mentioned: [Pg.49]    [Pg.50]    [Pg.51]    [Pg.51]    [Pg.51]    [Pg.51]    [Pg.52]    [Pg.56]    [Pg.59]    [Pg.60]    [Pg.66]    [Pg.193]    [Pg.2159]    [Pg.258]    [Pg.119]    [Pg.532]    [Pg.149]    [Pg.708]    [Pg.4675]    [Pg.1026]    [Pg.50]    [Pg.58]    [Pg.64]    [Pg.67]    [Pg.70]    [Pg.83]    [Pg.105]    [Pg.240]    [Pg.243]   
See also in sourсe #XX -- [ Pg.118 , Pg.119 , Pg.120 ]



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Channel voltage

Gate voltage

Gated channels

Pyrethroid

Pyrethroids

Sodium channels

Sodium channels pyrethroids

Sodium voltage gated

Voltage sodium channel

Voltage-gated

Voltage-gated channels

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