Cervical tumors

Carcinoids, atypical carcinoids, small cell carcinomas, and large cell NE carcinomas have been reported as primary cervical tumors.All small cell cervical carcinomas studied to date have been cytokeratin-positive, and more than 90% have been positive for EMA. Reactivity for CEA with polyclonal antisera occurs in 77%. Small cell cervical carcinomas are positive for CK20 or TTF-1 in 14.3% and 20% of cases, respectivelyWith respect to NE markers, NSE is present in 95%, synaptophysin in 46%, chromogranin A in 43%, and CD57 in 37%. Similar frequencies of positivity for NE markers have been reported in more recent studies.These tumors may also contain peptide and amine hormones including serotonin (31%), ACTH (23%), and somatostatin (8%). 

Ronnett BM, Yemelyanova AV, Vang R, et al. Endocervical adenocarcinomas with ovarian metastases Analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol. 2008 32 1835-1853. 

Table I. Carboplatin-DNA adducts Tattomol adduct/ug DNA) in cervical tumor and nucleated blood cell DNA of patients.

Fig. 7.6a,b. Comparison CT and MRL a No cervical tumor can be delineated in the sagittal reconstruction of a CT scan, b A nodular cervical carcinoma is shown in the dorsal external cervix (arrow) in T2-weighted (T2w) sagittal MRl. Accessory finding leiomyoma of the dorsal uterine corpus... 

Anecdotal study in a patient with cervical 59 node metastases. No significant uptake of At into an excised node. Poorly differentiated tumor... 

In humans methylene chloride exposure has been associated with a wide variety of cancers in a number of cohort and case control studies pancreatic, prostate, lung, liver, cervical, breast, and astrocytic brain tumors have been reported. Limitations in these studies include small sample size, incomplete exposure information, and concomitant exposure to other carcinogenic substances. The lARC has stated that there is not a sufficiently consistent elevation of risk across studies to make a causal interpretation credible. In a recent study of 1473 workers, followed for nearly 50 years, methylene chloride exposure level was not related to mortality due to all causes, malignant neoplasms, or lung and pancreatic cancers. ... 

Brizel DM, Rosner GL, Prosnitz LR, et al. Patterns and variability of tumor oxygenation in human soft tissue sarcomas, cervical carcinomas, and lymph node metastases. Int J Radiat Oncol Biol Phys 1995 Jul 15 32(4) 1121—1125. 

Mlb Nonregional lymph nodes and/or other distant metastasis Tumors of the upper thoracic esophagus Mia Metastasis in cervical nodes Mlb Other distant metastasis... 

In women with lower-genital-tract carcinomas—cervical, vaginal, and vulvar carcinomas—hematogenous metastases are rarely present at diagnosis, and thus disease can frequently be controlled with local treatment. Small tumors can usually be treated with surgery alone, but cancers that penetrate deeply, particularly those that involve adjacent... 

Vaginal cancers are so similar to cervical cancers with respect to epidemiology, behavior, and treatment response that many clinicians have chosen to treat vaginal cancers of stage II or greater with chemoradiation on the basis of results from cervical cancer trials. Unfortunately, only scattered published reports of chemoradiation are available for this rare tumor. 

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