Vaginal cancer

Gallbladder disease, hepatic adenoma, pancreatitis, thrombosis of abdominal artery or vein Endometrial, cervical, or vaginal cancer Deep vein thrombosis... 

Beef and DES (1972, US) Diethystilbestrol-for use as a cattle growth stimulant. DES is an estrogen, and all estrogens are animal carcinogens (FDA approved in 1954) caused vaginal cancer... 

Gardasil is a noninfectious recombinant vaccine consisting of capsid proteins from four different human papillomaviruses (HPVs) of types 6,11, 16, and 18. HPV causes squamous cell cervical cancer and cervical adenocarcinoma, as well as 35-50% of vulvar and vaginal cancers. 

DiethylstUbestrol (DBS), taken in the late 1950s and early 1960s to prevent miscarriages and also nsed as an animal fattener, was reported to canse vaginal cancer in the danghters of these women as well as prematnre deliveries, miscarriages, and infertility. 

A series of investigations initiated during this period led to the conclusion that DBS use by the mothers of these young women was the causative factor. Diethylstilbestrol is a developmental toxicant, because its effect was the result of exposures received in utero, but that effect - a rare form of vaginal cancer - was not fully expressed for about two decades following the exposure (the age at which the incidence of the disease peaked was later shown to be 19). The DES produced not only cancer but abnormalities of the sexual organs in both male and female offspring, most of which were not expressed until the children passed the age of puberty. 

Vaginal cancers are so similar to cervical cancers with respect to epidemiology, behavior, and treatment response that many clinicians have chosen to treat vaginal cancers of stage II or greater with chemoradiation on the basis of results from cervical cancer trials. Unfortunately, only scattered published reports of chemoradiation are available for this rare tumor. 

Pan, P. C. The application of Chinese Z0313 traditional medicine in the treatment of vaginal cancer. Chin J Obstet Gynecol 1960 8 156-162. 

Okada, H. Sakura, R. Kawaji, H. Yashiki, T. Mima, H. Regression of rat mammary tumors by a potent luteinizing hormone-releasing hormone analogue (leuprolide) administered vaginally. Cancer Res. 1983, 43, 1869-1874. 

Moroni M, Porta C. Possible efficacy of allopurinol vaginal washings in the treatment of chemotherapy-induced vaginitis. Cancer Chemother Pharmacol 1998 41(2) 171-2. 

Case-control studies have been used extensively to assess the safety of pharmaceuticals. There are many examples of case-control studies that have identified important associations between drugs and adverse health events vaginal cancer and diethylstilbestrol, Reye s syndrome and aspirin, peptic ulcer disease and nonsteroidal antiinflammatory drugs, and venous thromboembolism and oral contraceptives. Data from case-control studies are used to calculate an odds ratio, which is the ratio of the odds of developing the disease for exposed patients to the odds of developing the disease for unexposed patients. 

Cervical, endometrial, or vaginal cancer Breast cancer... 

Most of the cancer forms are designated on the basis of their occurrence in the particular part of the body, e.g., breast cancer, brain cancer, bladder cancer, liver cancer, lung cancer, ovarian cancer, stomach cancer, vaginal cancer and so on. Different types of cancer can behave very differently. For example, lung cancer and breast cancer are very different diseases. They grow at different rates and respond to different treatments. 

C) Infertility and development of vaginal cancer in female offspring... 

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