Cell lines cancerous versus

Metallointercalators that selectively and efficiently target single base mismatches have found several applications both as biologic probes and as potential chemotherapeutic agents. For instance, [Rh(bpy)2phzi] + was used to probe the relative frequency of mismatched sites in cell lines deficient versus proficient in their mismatch repair machinery (18). The relative cleavage observed with the phzi complex in healthy cell lines was low compared with that in cancer cell lines that carried mutations in essential repair proteins. These results support previous studies on the association of mismatch repair deficiency and cancer. 

The provocative initial biological activities reported for PatA, primarily the 20,000-fold difference in toxicity toward cancer cells (P388) versus a quiescent cell line (BSC) (Northcote et al, 1991), led us to undertake a total synthesis of this natural product that would ultimately enable detailed mode of action studies. We envisioned the synthesis and subsequent union of three principal fragments, namely, enyne acid 4, /1-lactam 10, and dienylstannane 14 (Fig. 14.1). A crucial aspect of this plan was a late-stage Stille coupling to append the expected labile trienyl... 

PPl (8) and its pyrazolopyrimidine analog PP2 (9) [99-108] were first described as potent inhibitors of SFKs with marked selectivity versus ZAP-70, JAK2, EGF-R, and PKA kinases. PPl provided an early key inhibitor of Src kinase to enable determination of its roles in VEGF-mediated angiogenesis and vascular permeability, Src-driven human breast cancer cell lines with respect to both heregulin-dependent or independent growth, and Src-related,... 

Chang et al., 2007], and in a Chinese case-control study based on 254 cases (OR 0.51 for more than 32.8 mg/day versus less than 11.6 mg/day of intake) [Zhang et al., 2004]. The evidence of an inverse association between isoflavones and ovarian cancer risk is supported by the observation that isoflavones have antiestrogenic effects [Ross and Kasum, 2002] and hence may inhibit the growth and proliferation of ovarian cell lines [Gercel-Taylor et al., 2004 Lukanova and Kaaks, 2005 Spinella et al., 2006],... 

Rubinstein, L.V. et al. 1990. Comparison of in vitro anticancer drug screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J. Natl. Cancer Inst. 82, 1113-1117. 

Seghal, I., Bailey, P. A., and Thompson, T. C., Transforming growth factor beta 1 stimulates contrasting responses in metastatic versus primary mouse prostate cancer-derived cell lines in vitro. Cancer Res. 56, 3359-3365 (1996). 

Socinski MA, Schell Ml, Peterman A, et al. Phase 111 trial comparing a defined duration of therapy versus continuous therapy followed by second-line therapy in advanced-stage IIIB/IV non-small-cell lung cancer. J Clin Oncol 2002 20 1335-1343. 

Mavroudis D, Papadakis E, Veslemes M, et al. A multicenter randomized clinical trial comparing paclitaxel-cisplatin-etoposide versus cisplatin-etoposide as first-line treatment in patients with small-cell lung cancer. Ann Oncol 2001 12 463 70. 

Rubinstein LV, Shoemaker RH, Pauli KD, Simon RM, Tosini S, Skehan P, Scudiero DA, Monks A, Boyd MR (1990) Comparison of in vitro Anticancer-Drug-Screening Data Generated with a Tetrazolium Assay versus a Protein Assay Against a Diverse Panel of Human Tumor Cell Lines. J Nat Cancer Inst 82 1113... 

Dangles-Marie, V, Pocard, M., Richon, S., Weiswald, L.B., Assayag, R, Saulnier, R, Judde, J.G., Janneau, J.L., Auger, N., Validire, R, Dutrillaux, B., Praz, R, Bellet, D., and Poupon, M.R (2007) Establishment of human colon cancer cell lines from fresh tumors versus xenografts comparison of success rate and cell line features. Cancer Res. 67, 398 07. 

Recently, researchers have been moving towards utilizing more active targeting approaches to improve the binding specificity of nanoshells toward specific cell types. In systemic circulation, this correlates with preferential accumulation of nanoshells in tumors versus normal tissue, which may lead to reduced nanoshell dosages. Thus far, breast and brain cancer cell lines have both been used as models for antibody-labeled nanoshell therapy. 

M.A. Socinski, I. Bondarenko, N.A. Karaseva, A.M. Makhson, I. Vynnychenko, I. Okamoto, J.K. Hon, V. Hirsh, R Bhar, H. Zhang, J.L. Iglesias, and M.E Renschler, Weekly nab-pacH-taxel in combination with carboplatin versus solvent-based paclitaxel plus carboplatin as first-line therapy in patients with advanced non-small-cell lung cancer Final results of a phase III trial,/Clin Oncol, 30 (17), 2055-62, 2012. 

Several derivatives of quinoline scaffold with a flexible, semi-flexible or rigid side chains at position 8 of the quinoline ring were synthesized by Arafa et al. [25], Studied in-vitro activity versus the human colon cancer cell line HT29 and the human breast cancer cell line MDA-MB231. The derivatives with Schiff s base linkers showed excellent activity. 

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