Antiestrogenic effects

In the E-Screen bioassay, LAS was not effective in promoting cell proliferation (Table 7.3.3). This compound was tested at concentrations of up to 100 pM with no evidence of cellular toxicity. The antiestrogenic effect of this compound was also measured but all samples tested were negative. Because it has been suggested that surfactants of the alkylbenzene sulfonate type are readily degradable and transformed into sulfophenyl carboxylates or SPCs, an important number of SPCs were assayed in the E-Screen test. These SPCs did not induce cell proliferation of MCF7 cells. 

Kannan et al. (2005) HHCB was found in all human fat tissue examined where 86% contained AHTN, and the former was always detected in greater concentration than AHTN possibly because HHCB is produced/manufactured and used in larger quantities than AHTN. High concentrations of HHCB also have been encountered in Lake Michigan compared to AHTN (Peck and Hombuckle, 2004), and both HHCB and AHTN have also been detected in mothers milk (Rimkus and Wolf, 1996). Musks have some antiestrogenic effects (Schreurs et al., 2004). 

Schreurs R.H.M.M., J. Legler, E. Artola-Garicano, T.L. Sinnige, P.H. Lanser, W. Seinen, and B. van der Burg (2004). In vitro and in vivo antiestrogenic effects of polycyclic musks in Zebrafish. Environmental Science and Technology 38 997-1002. 

In another study, the adverse effects of the antiestrogenic effects of clomiphene citrate were hot flushes (10%), mood swings, depression, headaches (1%), pelvic pain (5.5%), nausea (2%), breast tenderness (2-5%), dryness and loss of hair (0.3%), visual symptoms, halos and streaks around lights (particularly at night), blurring, and scotoma (1.5%) (3). 

Chang et al., 2007], and in a Chinese case-control study based on 254 cases (OR 0.51 for more than 32.8 mg/day versus less than 11.6 mg/day of intake) [Zhang et al., 2004]. The evidence of an inverse association between isoflavones and ovarian cancer risk is supported by the observation that isoflavones have antiestrogenic effects [Ross and Kasum, 2002] and hence may inhibit the growth and proliferation of ovarian cell lines [Gercel-Taylor et al., 2004 Lukanova and Kaaks, 2005 Spinella et al., 2006],... 

Antiestrogenic effects, Ti(IV) complexes, 4, 663 Antifouling coatings, silicones, 3, 677... 

Astroff B, Safe S. 1990. 2,3,7,8-Tetrachlorodibenzo-p-dioxin as an antiestrogen Effect on rat uterine peroxidase activity. Biochem Pharmacol 39 485-488. 

Zheng Y et al (2007) Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. Drug Metab Dispos 35 1942-1948... 

Raloxifene Like tamoxifen, which is also a SERM (see p 266), raloxifene s [ra LOCKS ih feen] actions are mediated through the estrogen receptors, and it has both estrogenic and antiestrogenic effects. Its clinical use is based on its ability to decrease bone resorption and overall bone turnover. However, unlike estrogen and tamoxifen, it apparently has little to no effect on the endometrium, and therefore may not predispose to uterine cancer. Raloxifene lowers total cholesterol and LDL in the serum, but has no effect on HDL or triglycerides. [Note Whether the latter... 

Comparison of the estrogenic and antiestrogenic effects of raloxifene and tamoxifen. 

In Vitro and in Vivo Antiestrogenic Effects of Polycyclic Musks in Zebrafish... 

Table 11. Physico-chemical properties, bioconcentration factors on a wet weight basis (BCFw) and on a lipid basis (BCFl), and estrogenic or antiestrogenic effects of Mirex and Chlordecone (Kepone)... 

ER-p, has approximately seven times the affinity for isoflavones, which may have extremely high blood levels when taken in the diet or in nutraeeutieal supplements. These may exert an antiestrogenic effect when estrogen levels are low, namely at menopause. 

Although oral administration of 3,000 mg/kg/day unleaded gasoline to female mice for 3 days resulted in a three-fold increase in estrogen metabolism in isolated hepatocytes, there were no functional antiestrogenic effects as assessed by uterotrophic assays (Standeven et al. 1994b). 

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