Apoptosis EGCG-induced

It has been shown that EGCG-induced apoptosis, cell-growth inhibition, and cell-cycle dysregulation in human prostate cancer DU145 and LNCaP cells without producing similar effects in normal cells [Ahmad et al., 1997 ... 

It was noticed that BTND and EGCG induce apoptosis in the transformant of JB6 cells. These transformant cells were prepared by the treatment of JB6 cells with A-ethyl-A -nitro-iV-nitrosoguanidine. Apoptotic cells were detected... 

Figure 7.1 Activation of caspase 3-mediated apoptosis in skin cancer cells A-431 by EGCG. A. Control cells without EGCG exposure. B. Cells exposed to 50 pM for 24 h. C. EGCG dose-dependently induced the activation of caspase 3 in A-431 cells during a 24-h period. The caspase 3 activity measured by the cleavage of a substrate peptide increased by two-, six-, and ninefold compared to control when cells were exposed to 25, 50, and 100 pM of EGCG, respectively.

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