Cell adhesion molecules integrins

Integrins are members of a laige family of transmembrane proteins that act as receptors for cell-adhesion molecules. Integrins are heteromeric proteins. The type of integrin expressed on the surface of a cell determines what kind of adhesion molecules and hence which cells can be bound. 

Integrins, selectins, cadherins, claudins and other cell adhesion molecules are involved in the interaction of cells with other cells or with extracellular matrix components. Some of them also serve as receptors by inducing outside-in or additional inside-out signaling. 

A 3D model of the fibrinogen-derived (very late antigen-4, VLA-4) inhibitor 4-[N -(2-methylphenyl)ureido]phenylacetyl-Leu-Asp-Val was derived from the X-ray structure of the related integrin-binding region of the vascular cell adhesion molecule-1 (VCAM-1). A 3D pharmacophore was generated with the program Catalyst, and a 3D search was performed in 8624 molecules from... 

LFA-1 Leucocyte function-associated antigcn-1 also known to be member of the (3-2 integrin family of cell adhesion molecules... 

Milner, R. and Campbell, I. L. The integrin family of cell adhesion molecules has multiple functions within the CNS. J. Neurosci. Res. 69 286-291,2002. 

Adhesion molecules such as LI, neural cell adhesion molecule (N-CAM) and N-cadherin promote axonal regeneration by homophilic interactions between axons and Schwann cell surfaces (see Ch. 7). The expression of p75 (low affinity NGF receptor, Ch. 27) is also increased at the Schwann cell surface after injury. Extracellular matrix molecules, such as tenascin and proteoglycans, increase the regenerative potential of damaged peripheral nerves by binding to integrins on the axonal surface. 

Natalizumab (Tysabri ) is a recombinant humanized IgG4 mAb that binds to the a4-integrin subunit of a4(31 (VLA-4) and oA M (LPAM-1) integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the a4-mediated adhesion of leukocytes to their respective receptors.103 104 The receptor for a4pi, vascular cell adhesion molecule-1 (VCAM-1), is expressed on activated endothelial cells and is... 

Albelda, S. M., Buck, C. A. (1990). Integrins and other cell adhesion molecules. FASEB J. 4, 2868-80. 

Another family of cell adhesion molecules, the integrins, are the components of plasma membranes responsible for maintaining the link between cells and their extracellular associations. This link is not only mechanical but allows communication. 

Aplin, A.E., Howe, A., Alahari, S.K., Jiiliano, R.L. (1998) Signal transduction and signal modulation by cell adhesion receptors the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol. Rev. 50, 197-263. 

Other cell adhesion molecules. Long before the discovery of integrins another class of transmembrane adhesion molecules were recognized as members of the immunoglobulin family. These were called cell... 

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