Furosemide Ceftazidime

Noninterfering acetaminophen, acyclovir, allopurinol, amoxicillin, amphotericin B, am-picillin, aspirin, azlocillin, bendrofluazide, bumetanide, buprenorphine, carbenidllin, cefazolin, cefotaxime, cefoxitin, ceftazidime, cefuroxime, cephalexin, chlorambucil, chloramphenicol, chlordiazepoxide, chlorpheniramine, chlorpropamide, cyclophosphamide, cyclosporin, C5d arabine, daunorubicin, dextropropoxyphene, dihydrocodeine, domperidone, flucytosine, furosemide, gentamicin, griseofulvin, melphalan, methotrexate, metochlo-pramide, metronidazole, miconazole, nabilone, netilmicin, nicotinamide, nitrazepam, penicillin G, piperacillin, prednisolone, procarbeizine, prochlorperazine, riboflavin, rifampin, sulfamethoxazole, thioguanine, tobramycin, tolbutamide, trimethoprim... 

The nephrotoxic effects of cefaloridine and possibly cefalotin or cefacetrile appear to be increased by furosemide. Cefradine brain levels are reduced by furosemide. No important interactions appear to occur between furosemide and cefoxitin, ceftazidime, ceftriaxone, or cefuroxime. 

A clinical study found that furosemide 80 mg increased the serum half-life of cefaloridine by 25%, and in another study cefaloridine clearance was reduced by fiirosemideA fiirther study found that brain concentrations of cefradine are markedly reduced by furosemide. In a study in 6 healthy subjects, furosemide 40 mg, given 1 hour before a 1-g intramuscular dose of ceftazidime, raised the serum ceftazidime levels by about 20 to 40% over 8 hours and increased the AUC by 28%. Furosemide given 3 hours before ceftazidime had much smaller effects." The serum half-lives of intravenous cefoxitin and cefiiroxime were not affected by oral furosemide. Ceftriaxone does not appear to interfere with the diuretic effects of furosemide. ... 

Although the manufacturers of ceftazidime issue a caution about the use of high doses of cephalosporins with other nephrotoxic drugs, they say that clinical experience has not shown this to be a problem with ceftazidime at the recommended doses.The rest of the information about other cephalosporins and furosemide is fairly sparse. Most appear not to interact adversely, with a few possible exceptions, namely cefalotin (nephrotoxicity in a single case and animal studies ) and cefacetrile (nephrotoxicity in animal studies ). Care is clearly prudent with these two cephalosporins. 

Carbon C, Dromer F, BrionN, Cremieux A-C, Contrepois A. Renal disposition of ceftazidime illusttated by interferences by probenecid, furosemide and indomethacin in rabbits. Antimicrob Agents Chemother (1984) 26, 373-7. 

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