Indometacin Ceftazidime

INDOMETACIN CEPHALOSPORINS Indometacin t ceftazidime levels in neonates Indometacin l clearance of ceftazidime 1 dose of ceftazidime... 

The clearance of ceftazidime is significantly reduced by Indometacin in neonates, and dosage adjustments are likely to be necessary. 

A study found the prenatal use of indometacin reduced the clearance of ceftazidime 25 mg/kg by 17.5% in 12 premature neonates (born at about 29 weeks) who were 10 days old. Further, in similar neonates who had not received indometacin, the clearance of ceftazidime increased over the first 10 days of life, but this was not seen when indometacin had been given. A further study by the same authors intended to establish an appropriate... 

---