Ceftazidime axetil

First-generation cephalosporins cefazolin for parenteral administration cefadroxil or cephalexin for oral administration. Second-generation cephalosporins cefuroxime for parenteral administration cefaclor, cefuroxime axetil, cefprozil, for oral administration. Third-generation cephalosporins ceftazidime, cefotaxime, ceftriaxone for parenteral administration cefixime, cefpodoxime, ceftibuten, cefdinir, cefditoren for oral administration. Fourth-generation cephalosporin cefepime for parenteral administration. Cephamycins cefoxitin and cefotetan for parenteral administration. 

Whereas many cephalosporins such as cefaclor, cefadroxil, cefonicid, ceforanide, ceftazidime, cefti-zoxime, cefuroxime, cephalexin, and cephradine are not metabolized, cefamandole naftate is rapidly hydrolyzed in plasma to cefamandole, which has greater antibacterial activity than the parent compound. Ceftriaxone is metabolized to a small extent to micro-biologically inactive metabolites in the intestines after biliary excretion. Cefuroxime axetil is rapidly hydrolyzed to cefuroxime, the microbiologically active form of the drug, by nonspecific esterases in the intestinal mucosa and blood following oral administration. The axetil moiety is further metabolized to acetaldehyde and acetic acid [93]. 

J.Pharm.Sci., 1994, 83, 553-558 [simultaneous degradation products cefuroxime axetil determined] Faouzi, M.A. Dine, T. Luyckx, M. Gressier, B. Brunet, C. Goudaliez, F. Mallevais, M.L. Cazin, M. Cazin, J.C. Stability and compatibility studies of cefaloridine, cefuroxime and ceftazidime with PVC infusion bags. Pharmazie, 1994, 49, 425-427 [simultaneous cefaloridine, ceftazidime saline 5% dextrose]... 

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