Cefoxitin Ceftazidime

Noninterfering acetaminophen, N-acetylprocainamide, amikacin, amitriptyline, ampicil-lin, carbamazepine, cefamandole, cefazolin, cefoperazone, cefotaxime, cefoxitin, ceftazidime, ceftizoxime, cephalexin, cephalothin, cephapirin, chloramphenicol, ciprofloxacin, clonazepam, (yclosporine, desipramine, digoxin, disopyramide, ethosuximide, gentamicin, haloperidol, imipramine, kanamycin, lidocaine, mezlocillin, netilmicin, nortriptyline, phenobarbital, phenytoin, primidone, procainamide, propranolol, quinidine, salicylic acid, streptomycin, sulfamethoxazole, theophylline, thiamphenicol, ticarcillin, tobramycin, trimethoprim, vancomycin... 

Noninterfering acetaminophen, acyclovir, allopurinol, amoxicillin, amphotericin B, am-picillin, aspirin, azlocillin, bendrofluazide, bumetanide, buprenorphine, carbenidllin, cefazolin, cefotaxime, cefoxitin, ceftazidime, cefuroxime, cephalexin, chlorambucil, chloramphenicol, chlordiazepoxide, chlorpheniramine, chlorpropamide, cyclophosphamide, cyclosporin, C5d arabine, daunorubicin, dextropropoxyphene, dihydrocodeine, domperidone, flucytosine, furosemide, gentamicin, griseofulvin, melphalan, methotrexate, metochlo-pramide, metronidazole, miconazole, nabilone, netilmicin, nicotinamide, nitrazepam, penicillin G, piperacillin, prednisolone, procarbeizine, prochlorperazine, riboflavin, rifampin, sulfamethoxazole, thioguanine, tobramycin, tolbutamide, trimethoprim... 

The nephrotoxic effects of cefaloridine and possibly cefalotin or cefacetrile appear to be increased by furosemide. Cefradine brain levels are reduced by furosemide. No important interactions appear to occur between furosemide and cefoxitin, ceftazidime, ceftriaxone, or cefuroxime. 

Penicillins (bactericidal inhibit cell wall crosslinking) e.g., benzylpenicillin, phenoyxmethylpenicillin, ampicillin, amoxicillin, flu-cloxacillin, methicillin, piperacillin Cephalosporins (bactericidal inhibit cell wall crosslinking) e.g., cefaclor, cefalexin, cefradine, cefuroxime, cefazolin, cefotaxime, ceftriaxone, cefoxitin, cefsulodin, ceftazidime, ceftizoxime Monobactams (bactericidal, P-lactam-like activity) e.g., aztreonam... 

First-generation cephalosporins cefazolin for parenteral administration cefadroxil or cephalexin for oral administration. Second-generation cephalosporins cefuroxime for parenteral administration cefaclor, cefuroxime axetil, cefprozil, for oral administration. Third-generation cephalosporins ceftazidime, cefotaxime, ceftriaxone for parenteral administration cefixime, cefpodoxime, ceftibuten, cefdinir, cefditoren for oral administration. Fourth-generation cephalosporin cefepime for parenteral administration. Cephamycins cefoxitin and cefotetan for parenteral administration. 

Example Compounds Cefaclor Cefadroxil Cefa-mandole Cefazolin Cefepidime Cefoperazone Cefotaxime Cefoxitin Ceftriaxone Cephalexin Cephalothin Cephradine Cephaprin Cefmeta-zole Cefonicid Ceforanide Cefotetan Cefprozil Loracarbef Cefperazone Cefpodoxime Cefix-ime Ceftazidime Ceftizoxime Moxalactarn... 

Parenterally administered cephalosporins that are metabolically stable and that are resistant to many types of (3-lactamases include cefuroxime, cefamandole, cefotaxime and cefoxitin, which has a 7(3-methoxy group at R2. Injectable cephalosporins with anti-pseudomonal activity include ceftazidime, cefsulodin and cefoperazone. 

Stiles, M.L. I i, Y.H. Allen, L.V., Jr. Stability of cefazolin sodium, cefoxitin sodium, ceftazidime, and penicillin G sodium in portable pump reservoirs. Am.J.Hosp.Pharm., 1989, 46, 1408-1412... 

The nephrotoxicity of various combinations of antibiotics was assessed in 171 cancer palienls. In Ihose receiving an aminoglycoside with a third generation cephalosporin, the most nephrotoxic combinations were found to be gentamicin with cefotaxime (although another study did not find this combination to be nephrotoxic ) and amikacin with ceftriaxone, where 5 of 20 and 5 of 13 patients, respectively, had increased serum creatinine. The following combinations were found to be safer amikacin with cefoxitin or ceftazidime, gentamicin with cefoxitin, and netilmicin with cefotaxime. ... 

Another study assessing the risk factors for nephrotoxicity with aminoglycosides (tobramycin and gentamicin) enrolled 1489 patients, 157 of whom developed clinical nephrotoxicity. Of these patients 118 had no immediately identifiable cause (such as acute renal failure) and further evaluation of other risk factors found that the concurrent use of cephalosporins (including cefazolin, cefotaxime, cefoxitin, cefamandole, ce-furoxime, ceftriaxone, and ceftazidime) significantly increased the risk of nephrotoxicity. ... 

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