Losartan potassium

Hydroserpine 2 Tablets—hydrochbrothiazide, reserpine Hyzaar—hydrochlorothiazide, losartan potassium Inderide—hydrochlorotliiazide, propranolol HC1 Inderide LA—hydrochlorotliiazide, propranolol HC1 Lexxel Extended-Release—enalapril maleate, felodipine Lopressor—hydrochlorothiazide, metoprolol Lotensin HCT—hydrochlorothiazide, benazepril Lotrel—amlodopine, benazepril... 

C22H22C1N,0 114772-55-3) see Losartan potassium tert-butyl chloroformate (C5H9CIO2 24608-52-4) see Cefalexin 2-butyl-4-chloro-5-hydroxymethyiimidazole (CSII13CIN2O 79047-41-9) see Losartan potassium 2-butyl-4-cbloro-lif-imidazole-5-carboxaldehyde (CnHiiClNjO 83857-96-9) see Eprosartan Losartan potassium... 

C4 H35C1N 0 120568-18-5) see Losartan potassium tert-butyl (4R,6S)-2-(6-cyanomethyl-2,2-dimcthyl-13-di-oxan-4-yl)acetale... 

C9H21BO3 5419-55-6) see Losartan potassium Rofecoxib triisopropyl phosphite... 

C,7H 5CI 76-83-5) see Candesartan cilexetil Cefotaxime Ceftazidime Indeloxacine Losartan potassium Remoxipride Zidovudine... 

C24H2,BN402 144873-97-2) see Losartan potassium 5 -0-(triphenylmethyl)thymidine 3 -methanesulfonate (CjoH,0N2O7S 42214-24-4) see Zidovudine... 

Adachi and Oka investigated the formation of cyanide during the reaction of chlorine with 20 different pharmaceuticals containing nitrogen in their molecular structure [90]. High levels of cyanide were generated by chlorination of hexamine and losartan potassium aqueous solutions. Other precursors of cyanide included metronidazol, dacarbazine, and allopurinol. 

Adachi A, Okano A (2008) Generation of cyanide ion by the reaction of hexamine and losartan potassium with sodium hypochlorite. J Health Sci 54(5) 581-583... 

USAN Losartan potassium Trade name Cozaai ... 

Losartan potassium (1), the prototype highly selective ATi receptor antagonist (Goa and Wagstaff, 1996), was derived from the Takeda series of l-benzylimidazole-5-acetic acid derivatives, which were themselves weak angiotensin II antagonists. Losartan potassium... 

The synthesis of losartan potassium (1) by the process research chemists at Merck is outlined in the following (Griffiths et ak, 1999 Larsen et al., 1994). Phenyltetrazole (8) is protected as the trityl phenyltetrazole 9 (Scheme 9.3). Ortho-lithiation of 9 followed by quenching with triisopropyl borate afforded boronic acid 10 after treatment with aqueous ammonium chloride. Reaction of glycine (11) with methyl pentanimidate (12) in a methanol/water mixture yielded (pentanimidoylamino) acetic acid (13), which underwent a Vilsmeier reaction with phosphorous oxychloride in DMF followed by hydrolysis to give imidazole-4-carbaldehyde 14 in moderate yield. 

Scheme 9.4. The Merck process synthesis of losartan potassium (1).

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