Lymphoepithelioma-like carcinoma

FIGURE 11.30 Delicately interlocking reactivity for keratin (K) in primary lymphoepithelioma-like carcinoma of the thymus. 

Lymphoepithelioma-like carcinoma, a subtype of primary large cell undifferentiated carcinoma, may occur as a primary lung cancer composed of large anaplastic cells and be confused with lymphomas and other neo-plasms.222 Most express low and high molecular weight... 

Butler AE, Colby TV, Weiss L, et al. Lymphoepithelioma-like carcinoma of lung. Am J Surg Pathol. 1989 13 632-639. 

FIGURE 14.11 Lymphoepithelioma-like gastric carcinoma. A, The large neoplastic cells have prominent nucleoli and blend in with the background inflammatory cells. B, An AEl /AE3 cytokeratin stain highlights the carcinoma cells. C, In this neoplasm, MLH-1 is lost in the tumor cell nuclei as compared with the intact (positive) staining of lymphocyte and stromal cell nuclei. D, In this example, the tumor cell nuclei are positive for Epstein-Barr virus mRNA (in situ hybridization) and the inflammatory and stromal cells are negative. 

MEDULLARY (LYMPHOEPITHELIOMA-LIKE) CARCINOMA Carcinoma with a medullary (lymphoepithelioma-like) morphology has been reported in the liver. These cases consist of poorly differentiated carcinoma (Hep Par-1... 

Chen CJ, Jeng LB, Huang SF. Lymphoepithelioma-like hepatocellular carcinoma. Chang Gung Med. 2007 30 172-177. 

Vortmeyer AO, Kingma DW, Fenton RG, et al. Hepatobiliary lymphoepithelioma-like carcinoma associated with Epstein-Barr virus. Am J Clin Pathol. 1998 109 90-95. 

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