Carcinogenity, metal compounds

S. Kawanishi, S. Inoue, and K. Yamamoto, Active oxygen species in DNA damage induced by carcinogenic metal compounds. Environ. Health Perspect. 102(suppl. 3) 17, 1994. 

Kawanishi S, Inoue S, Yamamoto K. 1989. Hydroxyl radical and singlet oxygen production and DNA damage induced by carcinogenic metal compounds and hydrogen peroxide. Biol Trace Elem Res 21 367-372. 

Landolph JR (1990) Neoplastic transformation of mammalian cells by carcinogenic metal compounds Cellular and molecular mechanisms. In Foulkes EC (ed.) Biological Effects of Heavy Metals. Metal Carcinogenesis, vol. II, pp. 1-18. Boca Raton, FL CRC Press. 

Hartwig, A. and Schwerdtle, T., Interactions by carcinogenic metal compounds with DNA repair processes toxicological imphcations, Toxicol Lett, 127,47,2002. 

Bertin G, Averbeck D (2006) Cadmium cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review). Biochimie 88(11) 1549-1559 Beyersmann D, Hartwig A (2008) Carcinogenic metal compounds recent insight into molecular and cellular mechanisms. Arch Toxicol 82(8) 493-512 Bode P, De Bruin M, Aalbers TG et al (1990) Plastics from household waste as a source of heavy metal pollution. An inventory study using INAA as the analytical technique. Biol Trace Elem Res 26-27 377-383... 

Pott, F., Ziem, U., Reiffer, F.J., Huth, F., Ernst, H. and Mohr, U. (1987). Carcinogenicity studies on fibres, metal compounds and some other dusts in rats. Exp. Pathol. 82, 129-152. 

IARC. 1980. IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Vol. 23 Some metals and metallic compounds. Lyons France World Health Organization, International Agency for Research on Cancer, 352-415. 

Stoner GD, Shimkin MB, Troxell MC, et al. 1976. Test for carcinogenicity of metallic compounds by the pulmonary tumor response in strain A mice. Cancer Res 36 1744-1747. 

Most metals, for which compounds are carcinogenic, are from IV group of Periodic Table of Elements. In biological systems, carcinogenic metals can form stable complexes and biological availability of these complexes determines the carcinogenic potential of various metal compounds. 

Mercuric chloride at low concentration, in comparison with other metal compounds, induced the least DNA repair [257], despite its demonstrated potency in producing DNA lesions, causing equivalently effective breakage in isolated DNA as well as in DNA from cells previously treated with Hg2 +. The degree of modification in DNA repair induced by mercuric chloride may explain why this agent is not severely mutagenic or carcinogenic [253]. 

Costa M, Mollenhauer HH. 1980. Carcinogenic activity of particulate metal compounds is proportional to their cellular uptake. Science 209 515-517. 

Capelli, M. Manfredi, V. R., Moretti, G. F., Trenti, A. (1991), in Carcinogenic and Mutagenic Metal Compounds 3. (Interrelation between Chemistry and Biology)-. Merian, E., Bronzet-ti, G. L., Haerdi, W. (eds.) New York Gordon and Breach. 

A variety of industrial materials, including metallic compounds (both organic and inorganic), are produced by multiple anthropogenic activities. Because of the manner of use and disposal, these often reach the environment and cause a plethora of potential health hazards.4 Of the above symptoms, the risk for CNS disturbances in a child s development or in the human adult has gained importance. Information concerning different metals (e.g., arsenic, cadmium, chromium, lead, mercury, many other compounds) and their possible carcinogenicity has been documented as a national priority in the literature (Table 3-1).6-1011... 

Beyersmann D, Koster A, Buttner B. 1985. Model reactions of chromium compounds with mammalian and bacterial cells. In MerianE, Fre RW, Hardi W, et al., eds. Carcinogenic and mutagenic metal compounds Environmental and analytical chemistry and biological effects. London, UK Gordon and Breach Science Publishers, 303-310. 

Hartwig A. 1998. Carcinogenicity of metal compounds possible role of DNA repair inhibition. 

Leonard A, Bernard A. 1993. Biomonitoring exposure to metal compounds with carcinogenic properties. Environ Health Perspect 101(3) 127-133. 

Carcinogenic and mutagenic metal compounds Environmental and analytical chemistry and biological effects. London Gordon and Breach Science Publishers, 119-125. 

---