Carcinogenic effects mortality risks

Chronic occupation-related exposure is associated with significant excess mortality from cancer of the respiratory system and of the prostate. Depending on the segment of the population considered, the respiratory cancer risk for coke oven workers was as high as 4.5 times the risk for nonoven workers. To evaluate a biologically effective exposure dose in human biomonitoring studies, DNA carcinogen adduct analysis is frequently used. 

The diet is believed to play an important role in the onset of carcinogenesis, and there are a number of carcinogens present in food, including mycotoxins, polycyclic hydrocarbons, and pesticides. Associations have been made between dietary fat intake and morbidity and mortality from breast and colon cancer. Another possible mechanism for the proposed protective effects against cancer of olive oil compared with sunflower oil involves diet-induced alterations in host immune responses. Both the type and concentration of dietary fats have been reported to influence immune status in several animal models. The PUFA Cigtz is necessary for T-cell-mediated immunity, but high intakes will suppress immune function and may therefore increase the risk of cancer. Furthermore, comparisons between the effects of diets rich in Ci8 2 and those rich in Cig i on varying indicators of immune function in mice have shown that, while dietary Ci8 2 predisposed... 

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