Carcinogenesis nickel compound

Gilman JPW. 1962. Metal carcinogenesis. 11. A study on the carcinogenic activity of cobalt, copper, iron and nickel compounds. Cancer Res 22 159-162. 

Verma R, Ramnath J, Glemens F, Kaspin RG, and Randolph JR (2004) Molecular biology of nickel carcinogenesis Identification of differentially expressed genes in morphologically transformed G3H/10T1/2 GI 8 mouse embryo fibroblast cell lines induced by specific insoluble nickel compounds. Molecular and Cellular Biochemistry 255 203-216. 

Injection site tumors are induced by many nickel compounds that do not cause cancer in animals by other routes of exposure. In fact, most of tihe published literature on nickel carcinogenesis concerns injected or implanted metallic nickel or nickel compounds these data are of limited value in determining carcinogenic exposure levels for avian and terrestrial wildlife. The applicability of these studies to a recommendation for human workplace exposure is also questionable. Nevertheless, injection or implantation site sarcomas have... 

Lee YW, Pons C, Tummolo DM, Klein CB, Rossman TG, Christie NT (1993) Mutagenicity of soluble and insoluble nickel compounds at the gpt locus in G12 Chinese hamster cells. Environ Mol Mutagen 21 365-371 Lee-Chen SF, Yu CT, Jan KY (1992) Effect of arsenite on the DNA repair of UV-irradiated Chinese hamster ovary cells. Mutagenesis 7 51-55 Leonard A (1984) Recent advances in arsenic mutagenesis and carcinogenesis. Toxicol Environ Chem 7 241-250... 

Sen P, Costa M. 1986a. Incidence and localization of sister chromatid exchanges induced by nickel and chromium compounds. Carcinogenesis 7 1527-1533. 

Sunderman FW Jr, McCully KS. 1983. Effects of manganese compounds on carcinogenicity of nickel subsulfide in rats. Carcinogenesis 4 461-465. 

Carcinogenicity. A number of metals have been shown to be carcinogenic in humans or animals. Arsenic, certain chromium compounds, and nickel are known human carcinogens beryllium, cadmium, and cisplatin are probable human carcinogens. The carcinogenic action, in some cases, is thought to result from the interaction of the metallic ions with DNA (see Chapter 11 for a detailed discussion of carcinogenesis). 

A number of metals (cadmium, cliromium, nickel, and cobalt) and related compounds have been implicated as carcinogens based upon epidemiological and experimental evidence. These metals are thought to act as primary carcinogens since no metabolic activation appears to bq involved. A characteristic of a primary metal carcinogen is that cancers are produced at the point of application. The carcinogenesis of nickel... 

Lung cancer is probably the most lethal manifestation of toxic effect from chronic exposure to certain chemicals. Asbestos fibers, coke oven emissions, arsenic, chromates, nickel and the radioactive gas, radon, are some of the substances known to cause lung cancer. For a detailed discussion of carcinogenesis, see Part A, Section VI, while specific compounds are discussed in Part B of this text. Acute and chronic effects of some common pulmonary toxicants are presented in Table V.3. 

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