2 carcinogenic actions

Cancerous skin lesions of workers exposed to pitch dust undoubtedly support the behef that these lesions are caused by polynuclear aromatic hydrocarbons, although it had not been possible to demonstrate their carcinogenic action in animals more closely related to humans, such as monkeys. 

Hurley, P. M., Hill, R, N., and W hiting, R. ]. (1998). Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents. Environ. Health Terspect. 106(8), 437-445. 

Baldwin RW, Cunningham GJ, Pratt D. 1964. Carcinogenic action of motor engine oil additives. Br J Cancer 18 503-507. 

Thus complete intercalation of the aromatic PAH between the bases of DNA, in the manner described above for flat molecule such as proflavine, did not seem to be a likely mechanism for the carcinogenic action of these compounds. Since alkylation and intercalation are not simultaneously possible for steric reasons, and since one molecule is wedge-shaped and the other is flatter, it was considered more likely that the action of these compounds arose from their alkylating ability they could alkylate a base of DNA and then, since the bulky aromatic hydrophobic group would possibly not remain protruding into the hydrophilic environment, it is possible that the aromatic PAH group could then lie in one of the grooves of DNA. 

Spitz S, Maguigan WH, Dobriner K. 1950. Tile carcinogenic action of benzidine. Cancer 3 789-804. 

Van Duuren BE, Langseth L, Gmldschmidt BM, et al Carcinogenicity of epoxides, lactones, and peroxy compounds. VI. Structure and carcinogenic action. J Natl Cancer Inst 39 1217-1228, 1967... 

Heston, W.E. Carcinogenic action of the mustards. J. Natl. Cancer Inst. 11 415-423, 1950. 

Gwynn, R.H., and Salaman, M.H. Studies on co-carclnogenesls SH-reactors and other substances tested for co-carcinogenic action in mouse skin. Br. J. Cancer 8 482-489, 1953. 

Griepentrog, F. (1973) [Pathological findings on the carcinogenic action of laboratory animals] Toxicology, 1, 93-102 (in German)... 

Host factors age-at-exposure The magnitude and temporal distribution of radiogenic cancers clearly depend on age-at-exposure, but in no simple, uniform fashion. The dependence probably varies by tumor site. Of particular interest is the question whether e embryo or fetus is very much more sensitive to the carcinogenic action of ionizing radiation than the infant or the young child. Also of interest is the dependence of the temporal distribution of the ag at-exposure effect on the age-specific pattern of natural incidence. 

Osswald, H. Kruger, F.W. (1969) Carcinogenic action of 1,2-dimethylhydrazine in the golden hamster. Arzneim. Forsch., 19, 1891-1892 (in German)... 

Steinhoff, D., Mohr, U. Schmidt, WM. (1990) On the question of tlie carcinogenic action of hydrazine—evaluation on the basis of new experimental results. Exp. Pathol., 39, 1-9... 

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