Carcinogenesis Initiator

Multi-causal, Multi-stage Nature of Carcinogenesis (Initiation, Co-cardnogenesis, Promotion, Progression)... 

Goerttler, K. and Laehrke, H. (1976). "Diaplacental carcinogenesis initiation with the carcinogens dimethyl-benzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage BerenblumyMottram experiment, Virch. Arch. Path. Anat. HistoL 372,29. 

Maruyama, H., Amanuma, T., Nakac, D., Tsutsumi, M., Kondo, S., Tsujiuchi, T., Denda, A., Konishi, Y. (1991) Effects of catechol and its analogs on pancreatic carcinogenesis initiated by A-nitrosobis(2-oxopropyl)anune in Syrian hamsters. Carcinogenesis, 12, 1331-1334... 

Konishi, Y. (1991) Effects of catechol and its analogs on pancreatic carcinogenesis initiated... 

Cancer prevention is now one of the most urgent projects in public health. It is evident that an understanding of the mechanisms of the carcinogenesis process is essential for cancer chemoprevention. Most cancer prevention research is based on the concept of multistage carcinogenesis initiation —> promotion — progression [2-4] [Fig. (1)]. Cancer chemoprevention is defined as the use of specific natural and... 

Evaluates the two-stage concept of carcinogenesis (initiation and promotion)... 

Fukushima, S., Friedell, G. H., Jacobs, J. B., and Cohen, S. M., Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide, Cancer Res., 41, 3100, 1981. 

Sakata, T., Shirai, T., Fukushima, S., Hasegawa, R., and Ito, N., Summation and synergism in the promotion of urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)-nitrosamine in F344 rats, Gann, 75, 950, 1984. 

Majima, T., Tsutsumi, M., Nishino, H., Tsunoda, T., and Konishi, Y., Inhibitory effects of betacarotene, pahn carotene, and green tea polyphenols on pancreatic carcinogenesis initiated by N-nitorsobis (2-oxopropyl)amine in Syrian golden hamsters, Pawerea, 16,13,1998. 

Resveratrol has been reported to inhibit all three stages of carcinogenesis initiation, progression, and promotion in several types of cancer. Several reports suggested that resveratrol inhibits cancer initiation in various model systems. Sharma et al. found that resveratrol reduced 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced free-radical formation in human promyelocytic leukemia cells HL-60. In another model, resveratrol also inhibited 7,12-dimethylbenzfi3)anthracene (DMBA)-induced preneoplastic lesion in... 

Two stage mouse skin carcinogenesis initiated with dimethylbenzanthracene (DMBA) and promoted with TPA Topical application of astilbin or (+)-taxifolin exhibited significant inhibitory effect. 

Two stage mouse pulmonary carcinogenesis initiated with 4-nitroquinoline-N-oxide and promoted with glycerol Oral administration of astilbin, (+)-taxifolin or the extract showed potent inhibitory activities. 

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