Carboxymethyl ether

Carboxymethylcellulose Sodium. Carboxymethyl ether of cellulose sodium salt (Citmcel) (8) is a white granular substance soluble in water depending on the degree of substitution. It is equally soluble in cold and hot water and may be prepared by treating alkaU cellulose with sodium chloroacetate. 

Carboxymethylcelluloses (CMC). CarboxymethylceUulose [9004 2-6] (CMC) is the carboxymethyl ether of cellulose. To prepare CMC, cellulose is steeped in sodium hydroxide solution, and the so-called alkaU cellulose is treated under controlled conditions with sodium monochloroacetate to form the sodium salt of CarboxymethylceUulose and sodium chloride. Therefore, the CMC of commerce is actuaUy sodium CarboxymethylceUulose... 

Calestani et al. [8] prepared dietylamide of the tetra-carboxymethyl ether of p-tert-h W.y calix[4]arene and reported alkali metal picrate extraction constants of 1.9... 

Cadexomer-H is an iodophor similar to povidone-iodine. It is a 2-hydroxymethylene crosslinked (1-4) a-D-glucan carboxymethyl ether containing iodine. The compound is used especially for its absorbent and antiseptic properties in the management of leg ulcers and pressure sores where it is applied in the form of microbeads containing 0.9% iodine. 

By the action of relatively small quantities of sodium chloroacetate on alkali cellulose, carboxymethyl ethers are obtained which give smooth solution in dilute alkali but which can be regenerated to give threads or films of high tensile strength. These products are relatively hygroscopic. The substances are soluble in the form of their sodium salts and form insoluble salts with many metals.8... 

Cellulose may be converted from a water-insoluble polymer to a water-soluble polymer by the partial etherification of some of the hydroxyl groups by dimethyl sulfate. When the degree of substitution (DS) is 1.5 to 2.0, the hydrogen bonds are sufficiently weakened, and the methylcellulose is soluble in water. Carboxymethyl ethers, such as carboxymethylcellulose (CMC), are also water-soluble. The degree of solubility is related to the DS of the polymer and the pH of the solvent. 

Total hydrolysis of the polymers gave D-glucose only. Water-soluble derivatives (ethyl or carboxymethyl ethers) of the polymers were unaffected by a-amylase, but were partially hydrolyzed by a ceUulase preparation from Acdobader xylinum. The optical rotations of several preparations of this polyglucose and of cellulose (P 1150) in tetraethylammonium hydroxide were all 0°, thereby strongly suggesting that the polyglucoses are /S-D-linked.109... 

Antiserum specific for the biologically more active X-pentazocine has been produced in rabbits using an -pentazocine-2 -carboxymethyl ether-bovine serum albumin conjugate. A low 0.08 cross-reactivity was found for [Pg.391]

A homolog of carboxymethylcellulose, the carboxyethyl derivative, can be prepared by the condensation of such acrylic derivatives as acrylamide with alkali-cellulose.30 The homolog is water-soluble, and gives a clear, viscous solution. Proposed uses are similar to those mentioned for the carboxymethyl ether. 

Omya, T. and Tabuchi, K. (1 985) Tamarind gum carboxymethyl ether alkali metal salts. Japanese Patent 60, 166, 302. 

Sodium starch glycolate is the sodium salt of a poly-ot-glucopyranose in which some of the hydroxyl groups are in the form of the carboxymethyl ether (Fig. 6). Starch is carboxymethylated by reacting it with sodium chloroacetate in an alkaline medium followed by neutralization with acid. Cross-linking is achieved by physical or chemical methods. The sodium starch... 

Guar gum is derivatized to modify its properties and functionalities. Available derivatives include the hydroxypropyl ether, the carboxymethyl ether, a cationic ether, a mixed hydrox-ypropyl cationic ether, the phosphate ester, and a mixed phosphate ester and cationic ether... 

The only anionic group added to cellulose is the carboxymethyl (-0-CH2-C02 ) ether group. To introduce the carbox)miethyl group, alkali cellulose is reacted with chloroacetic acid. (The carboxymethyl ether is also the ether of glycolic acid.) Also prepared commercially is car-boxymethylhydroxyethylcellulose. 

Cellulose, carboxymethyl ether, sodium salt, crosslinked [74811-65-7]... 

Carboxymethyl starch, sodium salt Explosol Explotab-, Glycolys Primojeh, starch carboxymethyl ether, sodium salt Tablo Vivastar P. 

The USPNF 23 states that sodium starch glycolate is the sodium salt of a carboxymethyl ether of starch, containing 2.8-4.2% sodium. 

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