Carbopol cosmetics

Carbopol is widely used in cosmetic and pharmaceutical practice as a gel-former. Carbopol resins are hydrophilic polymers which swell in water solutions and transform into the gel form at neutralization. At the elaboration of special cosmetic preparations in which carbopol is used, the problem of raw materials compatibility appears. For example, some extracts of aromatic pectin containing materials destroy the gel structure of carbopol. High contents of bivalent metal ions, in particular calcium ions, destructively influence onto the gel-making ability of the system too. 

Determination of Na " and Na" ions in raw cosmetic materials was conducted with the developed method of flame photometry. A necessity of development of method of samples preparation arose up in the work process, as this spicily-aromatic raw material contained pectin in amount 0.1-0.5% and that prevented preparation of samples by standard method of extracts dilution and required incineration of analyzed sample, time of analysis was increased in 60 times. It was established that CaCl, solution with the concentration 0,4 % caused destmctions of the carbopol gel. It was established that the addition of 0,1% CaCl, and 0,1% NaCl salts solutions into the system intensified the effect of negative action of these salts onto the gel stmcture and the gel destmcted completely. 

The determined macro- and microelement stmcture of mumio specifies onto the expediency of the application of this biologically active substance as a cosmetic raw material in the cosmetic compositions, which do not contain carbopol. The developed procedure for calcium and sodium ions determination in pectin-containing vegetative extracts is express and it is recommended for application at elaboration of cosmetic production compositions on the carbopol base. 

From a formulative point of view, it is important to take into consideration that the base in which liposomes are incorporated could also affect the drug delivery profile as well as the interactions between the liposomes and skin structures. The effect of formulation bases on dyphylline skin permeation from liposomes was examined by Touitou et al. [9]. In this work the effect of four bases for dyphylline liposomes (polyethylene glycol (PEG), carbopol gel, a PEG-enhancer base, and water) was studied. With these bases, the lowest skin permeation flux and a superior skin partitioning of liposomal dyphylline were reported for the PEG base, suggesting that this base favored dyphylline accumulation within the skin. A number of liposomes are currently marketed by cosmetic raw material companies for incorporation in different bases to obtain final products. It is important to keep in mind that the delivery properties of the final formulation could be altered by the vehicle used and should be tested to confirm any performance characteristics claimed. 

Lochhead RY, Hemker WJ, Castaneda JY. Hydrophobically modified carbopol resins. A new route to easily prepared, storage stable, cosmetic lotions that break upon contact with skin. Soap/Cosmetics/Chemical Specialties 1987 May 28-33 and 84-85. 

Uses Film-former, rheology control agent, emulsifier, stabilizer, moisturizer, thickener, gellant for cosmetic emulsions, skin care prods., topical pharmaceuticals emulsion stabilizer food-pkg. adhesives, coalings, paper/paperboard, polymers defoamer in food-contact coatings Trade Names Carbopol 1342 Carbopol 1382... 

Uses Colorant in cosmetics, pharmaceuticals Regulatory FDA 21CFR 74.1321, 74.2321, 82.1321 subject to certification, permanently listed Manuf./Distrib. Aldrich http //www.slgma-aldrlch.com, Costec http //www.costec.com, Noveon http //www.noveonlnc.com, http //WWW. carbopol. com, http //WWW.noveoncoatings.com. Sigma ... 

Uses Emulsifier, thickener, stabilizer, suspending agent used in cosmetics Carbopol 1706 [Lubrizol Advanced Materials]... 

Carbopol 971P NF Carbopol 974P NF suspending agent, cosmetic aerosols... 

---