Carayon

Rinaldi-Carmona, M., Le Duigou, A, Oustric, D., Barth, F., Bouaboula, M., Carayon, P., Casellas, P., Le Fur, G. Modulation of CB1 cannabinoid receptor functions after a long-term exposure to agonist or inverse agonist in the Chinese hamster ovary cell expression system, J. Pharmacol. Exp. Ther. 1998, 287, 1038-1047. 

L. Cloarec-Blanchard, C. Funck-Brentano, A. Carayon, and P. Jaillon. Rapid development of nitrate tolerance in healthy volunteers assessment using spectral analysis of short-term blood pressure and heart rate variability. J. Cardiovasc. Pharmacol. 24 266-273, 1994. 

Pohl M, Lombard MC, Bourgoin S, Carayon A, Benoliel JJ, Mauborgne A, Besson JM, Hamon M, Cesselin F. Neuropeptides 1989 14 151-159. 

Ruf J, Carayon P (2006) Structural and functional aspects of thyroid peroxidase. Arch Biochem Biophys 445 269-277... 

Ducloux D, Ottignon Y, Semhoun-Ducloux S, Labbe S, Saint-Hillier Y, Miguet JP, Carayon P, Chalopin JM. Mycophenolate mofetil-induced viUous atrophy. Transplantation 1998 66(8) 1115-16. 

Buchler M, Leibenguth P, Le Guellec C, Carayon A,Watier H, Odoul F, Autret-Lec, E, Lebranchu Y, and Paintaud G. 2004. Relationship between calcineurin inhibition and plasma endothelin concentrations in cyclosporine-A-treated kidney transplant patients. EurJClin Pharmacol 60 703-708. 

Feldt-Rasmussen U, Schleusener H> Carayon P. Metaanalysis evaluation of the impact of thyrotropin receptor antibodies on long term remission after medical therapy of Graves disease. J Clin Endocrinol Metab 1994 78 98-102. 

Baloch Z, Carayon P, Conte-Devobc B, Demers LM, Feldt-Rasmussen U, et al. Guidelines Committee, National Academy of Clinical Biochemistry. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease 2003 13 3-126. 

Bouaboula M, Desnoyer N, Carayon P, Combes T, CaseUas P (1999a) Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2 impUcation for intraceUular signalization cross-regulation. Mol Pharmacol 55 473-480... 

Galiegue S, Mary S, Marchand J, Dussossoy D, Carriere D, Carayon P, Bouaboula M, Shire D, LeFur G, CaseUas P (1995) Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 232 54-61... 

B lymphocytes have been reported to express relatively high levels of the CB2 receptor (Carayon et al. 1998 Galiegue et al. 1995 Lynn and Herkenham 1994). Thus, it is not surprising that cannabinoid agonists should exert major effects on their functional activities. Klein et al. (1985) noted that addition of THC to mouse splenocyte cultures suppressed not only T lymphocyte proliferation in response to the mitogens ConA and PHA, but also that of B lymphocytes induced by LPS, a B cell mitogen. The hydroxylated metabolite of THC, 11 -hydroxy-THC, was observed to be much less potent in this inhibition. 

Bouaboula M, Rinaldi M, Carayon P, Carillon C, Delpech B, Shire D, Le Fur G, Casellas P (1993) Cannabinoid-receptor expression in human leukocytes. Eur J Biochem 214 173-180... 

Carayon P, Marchand J, Dussossoy D, Derocq JM, Jbilo O, Bord A, Bouaboula M, Galiegue S, Mondiere P, Penarier G, Le Fur GL, Defrance T, CaseUas P (1998) Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-ceU differentiation. Blood 92 3605-3615... 

The possibility that the CB2 receptor plays a role in the control of immune cell fate is supported by studies on the gene expression profile ofhuman promyelocytic cells, which show that receptor activation up-regulates genes involved in the cell differentiation program (Derocq et al. 2000). These data, together with reports of CB2-induced blockade of neutrophilic differentiation (Alberich Jorda et al. 2003) and changes in CB2 receptor expression during the differentiation and activation ofhuman B cells (Carayon et al. 1998) point to an involvement of the CB2 receptor in the control of immune cell maturation. 

Smith M and Carayon P (1996). Work organization, stress and cumulative trauma disorders. In Beyond Biomechanics Psychosocial Aspects of Musculoskeletal Disorders in Office Work (S Moon and S Sauter eds), pp. 23-44. London, UK Taylor Francis. 

Carayon, M.T. and Lacout, J.L. (2003) Study of the Ca/P atomic ratio of the amorphous phase in plasma-sprayed hydroxyapatite coatings. J. Solid State Chem., 172, 339-350. 

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