Laboratory medicine

Theodore E. Warkentin Hamilton Regional Laboratory Medicine Program, Hamilton Health Sciences, and Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada... 

Girish Vyas1, William Babbitt2 department of Laboratory Medicine, University of California, San Francisco (UCSF), CA, USA 2UCSF School of Medicine, San Francisco, CA, USA... 

Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg Germany... 

Department of Laboratory Medicine University of California San Francisco, CA USA... 

Michael C. Jacobson, Department of Laboratory Medicine, University of Washington, Box 357110, Seattle, WA 98195-7110, USA Daniel A. Jaffe, University of Washington-Bothell, 22011 26 Avenue SE, Bothell, WA 98021, USA... 

Scientist, Research Instimte, Hospital for Sick Children, Toronto, and Associate Professor, Departments of Laboratory Medicine and Pathobiology and Department of Biochemistry, University of Toronto... 

Department of Laboratory Medicine, University of Connecticut School of Medicine, Farmington, Conn. 06032... 

Department of Pathology and Laboratory Medicine, Evanston Hospital, Evanston, 111. 6Q201... 

KAPLAN M and AVIRAM M (1999) Oxidized low density lipoprotein atherogenic and proinflammatoiy characteristics during macrophage foam cell formation. An inhibitory role for nutritional antioxidants and serum paraoxonase Clinical Chemistry Laboratory Medicine 37,111-9,1. 

Buttnee J (1995) The need for accuracy in laboratory medicine. Europ J Qin Chem Clin Bio-chem 33 981-988. 

Dybkaer R, Ornemark U, Uldall A, Richter W (1999) Metrology in laboratory medicine - A necessity. Accredit Qual Assur 4 349-351. 

McQueen MJ, Roberts HR, Siest G (1995) Reference materials and reference measurement systems in laboratory medicine - a major international meeting organized by the International Federation of Clinical Chemistry (IFCC), Geneva, October 5-7, 1994. Europ J Clin Chem Clin Biochem 33 977-999. 

Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universitd del Piemonte Orientale, 28100 Novara, Italy Department of Pathology and Laboratory Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA... 

Linder MW, Valdes R Jr. Pharmacogenetics in the Practice of Laboratory Medicine. Mol Diagnosis 1999 4 365-379. 

The properties of a pH electrode are characterized by parameters like linear response slope, response time, sensitivity, selectivity, reproducibility/accuracy, stability and biocompatibility. Most of these properties are related to each other, and an optimization process of sensor properties often leads to a compromised result. For the development of pH sensors for in-vivo measurements or implantable applications, both reproducibility and biocompatibility are crucial. Recommendations about using ion-selective electrodes for blood electrolyte analysis have been made by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) [37], IUPAC working party on pH has published IUPAC s recommendations on the definition, standards, and procedures... 

Lorian V (1996) Antibiotics in laboratory medicine, 4th edn. Williams and Wilkins, Baltimore... 

Gemmel GC, Lorian V Effects of low concentrations of antibiotics on bacterial ultrastructure, virulence, and susceptibility to immunod-efenses Clinical significance, in Lorian V (ed) Antibiotics in Laboratory Medicine, ed 4. Baltimore, Williams Wilkins, 1996, pp 397-452. 

The terminology used in this Standard is slightly different from the others in that it is appropriate for the particular discipline. For example, the term, referral laboratories in paragraph 4.5 of ISO 15189 is used in a slightly different sense to the comparable clause in ISO/IEC 17025. Included in this section are consultants who may provide a second opinion. If the referral laboratory is an external laboratory, to which samples are submitted for a supplementary or confirmatory examination procedure and report, it is much the same as a contract laboratory in ISO/IEC 17025. There is an extra Annex in this Standard which covers the ethics applicable to laboratory medicine. 

Schmitz, G., Aslanidis, C., and Lackner, K.J. 2001. Pharmacogenomics implications for laboratory medicine. Clinica Chemica Acta 308(1-2), 43-53. 

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455... 

Molecular research advances have created useful techniques that are complementary to routine testing within many sections of clinical laboratory medicine... 

Source Adapted from Zane HD. Immunology—Theoretical and Practical Concepts in Laboratory Medicine, Saunders Philadelphia, 2001. 

Wang, J., Electroanalytical Techniques in Clinical Chemistry and Laboratory Medicine, VCH, New York, 1988. A short book from the master himself. Not an easy read, though, as it seems to presuppose quite a lot of background material - but it is, after all, applied electroanalysis, as the title suggests. The chapter on ion-selective electrodes is dated in content but full of useful insights. 

Siest, G., Pillot, T., Regis-Baftly, A., Leininger-MuUer, B., et al. (1995) Apolipoprotein E an important gene and protein to foUow in laboratory medicine. Clin. Chem., 41, 1060-1086. 

Keren, D. F. (1989) Clinical molecular cytometry merging flow cytometry with molecular biology in laboratory medicine, in Flow Cytometry in Clinical Diagnosis (Keren, D. F., Hanson, C. A., and Hurtubise, P. E., eds.), Chicago, ASCP, pp. 614-634. 

Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine, Lund University Hospital, Lund, Sweden... 

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