Peripheral cannabinoid receptor

Johnston LD, O Malley PM, Bachman JG, et al Monitoring the Future National Results on Adolescent Drug Use Overview of Key Findings, 2003 (NIH Publ No 04—3506). Bethesda, MD National Institute on Drug Abuse, 2004 Jorda MA, Rayman N, Valk P, et al Identification, characterization, and function of a novel oncogene the peripheral cannabinoid receptor Cb2. Ann N Y Acad Sci 996 10-16, 2003... [Pg.178]

Facci L, Dal Toso R, Romanello S, Buriani A, Skaper SD, Leon A. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. Proc Natl Acad Sci USA 1995 92 3376-3380. [Pg.129]

Hanus L, Breuer A, Tchilibon S, Shiloah S, Goldenberg D, Horowitz M, Pertwee RG, Ross RA, Mechoulam R, Fride, E. HU-308 a specific agonist for CB2, a peripheral cannabinoid receptor. Proc Natl Acad Sci USA, 1999 25 14228-14233. [Pg.130]

A peripheral cannabinoid receptor was cloned from HL-60 cells. It is not expressed in the brain but in macrophages in the marginal zone of spleen. The peripheral cannabinoid receptor, mCB2, was cloned from a mouse splenocyte cDNAUbrary. This protein of347 residues shares 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and is shorter by 13 amino acids at the C-terminus. [Pg.58]

Palmitoylethanolamide, isolated from rat and quinea pig brains, was shown to exhibit antiinflammatory and analgesic activity even though it does not activate central and peripheral cannabinoid receptors. Palmitoylethanolamide binds with high potency (EC50 = 3.2 1.3 nM) to the orphan G-protein-coupled receptor GPR55, which as mentioned above, may represent a new cannabinoid receptor. [Pg.63]

Shire D, Calandra B, Rinaldi-Carmona M, Oustric D, Pessegue B, Bonnin-Cabanne O, Le Fur G, Caput D, Ferrara P, Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor, Biochim Biophys Acta 1307 132-136, 1996. [Pg.72]

Fride, E., Breuer, A., Hanus, L., Tchilibon, S., Horowitz, M., Mechoulam, R., Garzon, A. (Yissum Research Development Company of the Hebrew University), Agonist specific for the peripheral cannabinoid receptor, WO 0132169. [Pg.504]

A peripheral cannabinoid receptor (CB2) was later cloned from a human promyelocytic leukaemic line (HL60) [30], This receptor was shown to be only partially homologous with the brain receptor, and is expressed in cells of the immune system, predominantly on B-cells [31]. [Pg.204]

The existence of a peripheral cannabinoid receptor (CB2) led us to investigate the possibility that peripheral cannabinoid ligands, distinct from the... [Pg.209]

Jbilo O, Derocq J-M, Segui M, Le Fur G, Casellas P (1999) Sdmula-don of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocydc cell line HL60. FEBS Lett 448 273-277. [Pg.540]

Della Valle, F. Leon, A. Marcolongo, G. Lorenzi, S. Therapeutic use of mono and bicarboxylic acid amides active at the peripheral cannabinoid receptor 1999 US 5,990,170... [Pg.179]

Bayewitch M, Rhee M-H, Avidor-Reiss T, Brener A, Mechoulam R, Vogel Z (1996) (-)-zl9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylyl cyclase. J Biol Chem 271 9902-9905... [Pg.39]

Gallant M, Dufresne C, Gareau Y, Guay D, Leblanc Y, Prasit P, Rochette C, Sawyer N, Slipetz DM, Tremblay N, Metiers KM, LabeUe M (1996) New class of potent ligands for the human peripheral cannabinoid receptor. Bioorg Med Chem Lett 6 2263-2268... [Pg.42]

Portier M, Rinaldi-Carmona M, Pecceu F, Combes T, Poinot-Chazel C, Calandra B, Barth F, Le Fur G, Casellas P (1999) SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist. J Pharmacol Exp Ther 288 582-589... [Pg.48]

Showalter VM, Compton DR, Martin BR, Abood ME (1996) Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2) identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278 989-999... [Pg.49]

Bouaboula M, Poinot-Chazel C, Marchand J, Canat X, Bourrie B, Rinaldi-Carmona M, Calandra B, Le Fur G, CaseUas P (1996) Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. Eur J Biochem 237 704-711... [Pg.70]

Derocq JM, JbUo O, Bouaboula M, Segui M, Clere C, Casellas P (2000) Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation. J Biol Chem 275 15621-15628... [Pg.71]

Slipetz DM, O Neill GP, Favreau L, Dufresne C, Gallant M, Gareau Y, Guay D, Labelle M, Metiers KM (1995) Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase. Mol Pharmacol 48 352-361... [Pg.77]

Alberich Jorda M, Rayman N, Tas M, Verbakel SE, Battista N, Van Lorn K, Lowenberg B, Maccarrone M, Delwel R (2004) The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a hgand-dependent manner. Blood... [Pg.106]

Bouaboula M, Desnoyer N, Carayon P, Combes T, CaseUas P (1999a) Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2 impUcation for intraceUular signalization cross-regulation. Mol Pharmacol 55 473-480... [Pg.107]

Bouaboula M, Dussossoy D, CaseUas P (1999b) Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses. J Biol Chem 274 20397-20405... [Pg.107]

Chin C, Murphy J, Huffman J, Kendall D (1999) The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J Pharmacol Exp Ther 291 837-844... [Pg.107]

Galiegue S, Mary S, Marchand J, Dussossoy D, Carriere D, Carayon P, Bouaboula M, Shire D, LeFur G, CaseUas P (1995) Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 232 54-61... [Pg.108]

Tao Q, McAllister S, Andreassi J, NoweU K, Cabral G, Hurst D, Bachtel K, Ekman M, Reggio P, Abood M (1999) Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2) evidence for subtype specificity. Mol Pharmacol 55 605-613... [Pg.114]

Valk PJM, Llol S, Vankan Y, Ihle JN, Askew D, Jenkins NA, Gilbert DJ, Copeland NG, deBoth NJ, Lowenberg B, Delwel R (1997) The genes encoding the peripheral cannabinoid receptor and a-L-fucosidase are located near a newly identified common virus integration site. J Virol 71 6796-6804... [Pg.114]

On peripheral terminals, the activation of CBi and CB2 cannabinoid receptors was shown to inhibit nociceptive transmission, and both receptors seem to be implicated in mediating the existing endogenous cannabinoid tone (Calignano et al. 1998 Strangman et al. 1998 Hanus et al. 1999 Ko and Woods 1999). Thus, behavioural studies support a role for peripheral cannabinoid CB2 receptors in animal models of persistent pain and the existence of a synergism between CBi-and CB2 -mediated responses at this level (Malan et al. 2002). However, other studies do not support such a role of peripheral cannabinoid receptors (Di Marzo et al. [Pg.125]

Carayon P, Marchand J, Dussossoy D, Derocq JM, Jbilo O, Bord A, Bouaboula M, Galiegue S, Mondiere P, Penarier G, Le Fur GL, Defrance T, CaseUas P (1998) Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-ceU differentiation. Blood 92 3605-3615... [Pg.416]

Valk P, Verbakel S, Vankan Y, Hoi S, Mancham S, Ploemacher R, Mayen A, Lowenberg B, Delwel R (1997) Anandamide, a natural ligand for the peripheral cannabinoid receptor is a novel synergistic growth factor for hematopoietic cells. Blood 90 1448-1457... [Pg.423]

Johanek LM, Simone DA (2004) Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury. Pain 109 432-442... [Pg.548]

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