Cancer process progression

The most convincing data have been obtained from rodent models of cancers that revealed protective effects of curcumin against cancers of aU sites. Curcumin is able to inhibit all steps of cancer processes, initiation, progression, and promotion. These observations, combined with the apparent lack of toxicity of curcumin for doses up to 8 g/day for 3 mo suggest potential uses of curcumin as an anti-carcinogenic chemoprotective agent. ... 

TNF is a pleiotropic cytokine exerting a wide range of cellular responses, that affect biological processes such as lipid metabolism, coagulation, and insulin resistance and the function of endothelial cells. As a major proinflammatory cytokine TNF is also involved in progression of diseases like cancer, Alzheimer, Diabetes type II, cardiovascular, pulmonary or neurological disorders, and many autoimmune diseases. Blocking the action of TNF clearly reduces its inflammatory potential on various autoimmune disorders like Crohn s disease, rheumatoid arthritis (RA), and psoriasis. 

N-Nitrosamines are formed during processing and smoking of tobacco products. Proteins, agricultural chemicals and alkaloids in tobacco products serve as major precursors for volatile, nonvolatile, and tobacco-specific nitrosamines (Figure 1). In this review we will summarize the progress achieved in respect to tobacco nitrosamines since the last ACS symposium in Boston in June of 1978 (J ). Additional papers will review the metabolism of cyclic N-nitrosamines, including that of N -nitrosonornicotine 1) and the correlation between tobacco and alcohol consumption and cancer of the upper alimentary tract (J ). 

The process of cancerization in the stomach mucosa, therefore, seems to be a continuum of changes which turns a normal cell into a metaplastic cell and then to a progressively dysplastic cell and finally a cancerous cell. The changes usually take several decades, are gradual, and the change from one cell type to the other does not seem obligatory. They seem to reflect sequential mutations or cell transformations. 

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