Cancer organosulfur compounds

Herman-Antosiewicz A and Singh S V (2004), Signal transduction pathways leading to cell cycle arrest and apoptosis induction in cancer cells by Allium vegetable-derived organosulfur compounds a review , Mutation Res, 555, 121-131. 

Heber, D. (1997) The stinking rose organosulfur compounds and cancer [editorial comment]. Am. J. Clin. Nutr. 66 425 126. 

Takada N, Matsuda T, Otoshi T, et. al. Enhancement by organosulfur compounds from garlic and onions of diethylnitroasamine-induced glutathione S-transferase positive foci in the rat liver. Cancer Res 1994 54 2895-9. 

This review compiles recent studies on the chemistry and biological activities of the organosulfur compounds of garlic with special attention to the role of these compounds in preventing cancer. 

Sumiyoshi H, Wargovich MJ. Ghemoprevention of 1,2-dimethylhydrazine-induced colon cancer in mice by natural-occurring organosulfur compounds. Cancer Res 1990 50 5084-5087. 

Munday R, Munday CM. Relative activities of organosulfur compounds derived from onions and garlic in increasing tissue activities of quinone reductase and glutathione transferase in rat tissues. Nutr Cancer 2001 40 205-210. 

Yu FL, Bender W, Fang Q, Ludeke A, Welch B. Prevention of chemical carcinogen DNA binding and inhibition of nuclear RNA polymerase activity by organosulfur compounds as the possible mechanisms for their anticancer initiation and proliferation effects. Cancer Detect Prev 2003 27 370-379. 

Sundaram SC, Milner JA. Impact of organosulfur compounds in garlic on canine mammary tumor cells in culture. Cancer Lett 1993 74 85-90. 

Indole-3-carbinol, capsaicin, and allium-derived organosulfur compounds have all been studied with respect to their anticancer properties and mechanisms have been proposed. However, as pointed out by Lee and Park [21], evidence has also been put forward that each of these compounds possess properties that may promote or assist cancer development. 

Chapters 8-11 are devoted to consideration of two main classes of phytochemicals Chapter 8 centers on organosulfur compounds from the Allium genus, and their role in cancer prevention, while subsequent chapters are devoted to polyphenols and their wide-ranging effects against cancers, cataracts, and cardiovascular disease. Chapter 9 examines the cancer-protective and therapeutic potential of polymethylated flavonoids such as occur in citras, while Chapter 10 summarizes recent cancer chemopievention research in an area particularly relevant to the British and Chinese backgrounds of the editors, notably tea. A much less well-studied area, that of cataracts and their prevention by dietary flavonoids, is presented in Chapter 11. 

Bianchini, F. and Vainio, H., Allium vegetables and organosulfur compounds do they help prevent cancer Environ. Health Perspect, 109, 893,2001. 

Fukushima, S. Takada, N. Hori, T. Wanibuchi, H., Cancer prevention by organosulfur compounds from garlic and onion. Journal of Cellular Biochemistry (1997) 100—105. 

Wattenberg LW, Spamins VL, Barany G (1986) Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes. Cancer Res 49 2689-2692... 

Le Bon, A.M. and Siess, M.H. 2000. Organosulfur compounds from Allium and the chemopreven-tion of cancer. Drug Metabol Drug Interact 77(1-4) 51 79. 

Benkeblia N (2004) Antimicrobial activity of essential oil extracts of various onions (Allium cepa) and garhc (Allium sativum). LWT- Food Sci Technol 37 263-268 Benkeblia N, Lanzotti V (2007) Allium thiosulfinates chemistry, biological properties and their potential utihzation in food preservation. Food 1(2) 193-201 Bianchini F, Vainio H (2001) Allium vegetables and organosulfur compounds do they help prevent cancer. Environ Health Perspect 109(9) 893-902 Block E (1985) The chemistry of garhc and onion. Sci Am 252 114-119... 

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