Cancer hyperthermia

Cancer hyperthermia used in conjunction with chemotherapy. 

T. Kobayashi, Cancer hyperthermia using magnetic nanoparticles, Biotechnol. J. 6 (11) (2011) 1342-1347. 

Drug delivery systems, magnetic cell seeding, cell sheet construction, cancer hyperthermia treatment, cell expansion, tissue engineering scaffolds Dye-sensitized solar cells, soft implants, implantable biosensors and devices, drug delivery systems, tissue engineering scaffolds, advanced plastic materials... 

Abe, M. Hiraoka, M. (1990). Hyperthermia in combination with radiation in the treatment of cancers. In Stress Proteins in Biology and Medicine (Morimoto, R., Tissieres, A., Georgopoulos, C., eds.), pp. 117-130. CSHL Press, Cold Spring Harbor. 

M. Anbar, Hyperthermia of die cancerous breast — analysis of mechanism. Cancer Lett. 84, 23—29... 

Chemotherapeutic agents that have significant cancer response when combined with hyperthermia (up to 43°C) include doxorubicin, melphalan, mitomycin C (MMC), mitoxantrone, gemcitabine, etoposide, and especially the platinum-based agents carboplatin and oxaliplatin (Mohamed et al., 2003 Sugarbaker et al., 2005). Agents that do not work well with hyperthermia include irinotecan, paclitaxel, docetaxel, 5-fluorouracil, and floxuridine (Mohamed et al., 2003 Sugarbaker et al., 2005). 

Needham D, Anyarambhatia G, Kong G, Dewhirst MW. A new temperature-sensitive liposome for use with mild hyperthermia characterization and testing in human tumor xenograft model. Cancer Res 2000 60 1197-1201. 

Down-regulation of BRCA protein or interference of Rad51 foci formation has been reported for a variety of conditions including inhibition of CDKl (30), mild hyperthermia (31), hypoxia (32), loss of PTEN (33, 34), loss of PALB2 (35), or over-expression of EMSY (36). The BRCAness phenotype induced under all these conditions makes cancer cells more sensitive to PARP inhibition. The key is to develop a functional assay for BRCAness to enable stratification of cancer patients for clinical trials of PARP inhibitors. 

Krawczyk PM, Eppink B, Essers J et al (2011) Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly ADP-ribose polymerase-1 inhibition. Proc Natl Acad Sci USA 108 9851-9856... 

Brizel DM, Scully SP, Harrelson JM et al. Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. Cancer Res 1996 56(23) 5347-5350. 

The hallmark of a bacterial infection is fever due to LPS pyrogenicity. It may have some relevance in cancer as hyperthermia is tested as a cancer treatment on its own, as reviewed by Christophi et al. [58], This effect is mediated by cytokines (mainly IL-1(3) produced in response to LPS. 

Shinkai M, Suzuki M, Iijima S, et al. Antibody-conjugated magnetoliposomes for targeting cancer cells and their application in hyperthermia. Biotechnol Appl Biochem 1994 21 125-137. 

Kong, G., Anyarambhatla, G., Petros, W.P, et al. Efficacy of liposomes and hyperthermia in a human tumor xenograft model Importance of triggered drug release. Cancer Res. 60(24) 6950-6957. 2000. 

Cancer growth is slowed or stopped at temperatures in the range of 42-48 °C, while normal cells can tolerate even higher temperatures [167, 168], Heat treatments can be characterized as hyperthermia, in which the temperature is limited to less than about 50 °C, and thermal ablation, which involves higher temperatures. 

The first clinical human trials using magnetic hyperthermia were reported by Liibbe, et al. [70, 129, 137, 190] who used 100-nm starch-coated iron-oxide particles bound with epirubicin for treatment of advanced solid cancers. Jordan recently reported positive results from ongoing trials of advanced cancer patients who received magnetic nanoparticle hyperthermia in conjunction with conformal external beam radiation therapy [191]. The therapy was well tolerated by the patients and significant increases in the length and quality of life were observed. 

Hergt R, Dutz S, Miiller R, Zeisberger M (2006) Magnetic particle hyperthermia, nanoparticle magnetism and materials development for cancer therapy. J Phys Condens Matter 18 S2919-S2934... 

Pradhan P, Giri J, Banerjee R, Bellare J, Bahadur D (2007) Preparation and characterization of manganese ferrite-based magnetic liposomes for hyperthermia treatment of cancer. J Magn Magn Mater 311 208-215... 

Halm GM, Strande DP (1976) Cytotoxic effects of hyperthermia and adriamycin on Chinese hamster cells. J Natl Cancer Inst 57 1063-1067... 

Ultrasound in Cancer Therapy The use of ultrasound to enhance cancer therapy has been the subject of numerous biological and clinical investigations. In most of these studies, ultrasound has been used as an agent to induce hyperthermia for either direct treatment of small and localized cancerous tumors20-27 or as adjuvant therapy to increase the efficacy of radiotherapy and chemotherapy. 

In the first application, acoustic intensities of thousands of W/cm2 and tempera-tures in excess of 98°C are often used to coagulate cancerous tissues. This form of hyperthermia is often referred to as thermal therapy because of its extreme temperature and energy.43 Alternatively, lower ultrasound intensities (0.2 to several W/cm2) produce a mild increase in temperature (41 to 45°C), and enhance the cytotoxicity of radiation therapy and chemotherapy. The enhancing effect of ultrasound on radiation therapy has been linked to the radiosensitization effect of hyperthermia, which increases radiation damage and prevents subsequent repair.28 However, the precise mechanism for ultrasound-enhanced chemotoxicity is still the subject of debate. 

Hahn, G. M. Hyperthermia and Cancer. Plenum Press New York, 1982. 

Weinstein JN, Magin RL, Cysyk RL, et al. Treatment of solidL1210 murine tumors with local hyperthermia and temperature sensitive liposomes containing methotrexate. Cancer Res 1980 40 1388-1395. 

Tacker JR, Anderson RU. Delivery of anti-tumor drag to bladder-cancer by use of phase-transition liposomes and hyperthermia. J Urol 1982 127 1211-1214. 

There are a number of medical procedures which use heating or cooling to destroy pathological tissues such as cancer. These procedures include ablation, in which the tissue is heated rapidly to well above 343 K for short periods of time, hyperthermia, which heats tissue slowly to 315-318 K and maintains this temperature for extended periods, and cryotherapy, in which the tissue is... 

Calderwood, S. K., and Ciocca, D. R. (2008). Heat shock proteins stress proteins with Janus-like properties in cancer. Int J Hyperthermia 24(1), 31-39. 

Sakaguchi, Y., Maehara, Y., Baba, H Kusumoto, T Sugimachi, K., and Newman, R. A. (1992) Flavone acetic acid increases the antitumor effect of hyperthermia in mice. Cancer Res. 52, 3306-3309. 

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