Localized hyperthermia

Aoki, H., et al. 2004. Therapeutic efficacy of targeting chemotherapy using local hyperthermia and thermosensitive liposome Evaluation of drug distribution in a rat glioma model. Int J Hyperthermia 20 595. 

Aoki, H., Kakinuma, K., Morita, K., Kato, M., Uzuka, T., Igor, G, Takahashi, H., and Tanaka, R. (2004), Therapeutic efficacy of targeting chemotherapy using local hyperthermia and thermosensitive liposome Evaluation of drug distribution in a rat glioma model, Int. J. Hypertherm., 20, 595-605. 

Yatvin, M. B., Weinstein, J. N., Dennis, W. H., and Blumenthal, R. (1978), Liposomes and local hyperthermia Selective delivery of methotrexate to heated tumors, Science, 202,1290-1293. 

Carbazilquinone was very effective against the intramuscular (i.m.) Ehrlich ascites tumor when used with local hyperthermia (37-41°) and temporary interruption of blood flow.15 Mature ribosome formation was blocked by BCNU indicating that the effectiveness of this drug as a cell growth inhibitor may be due to the inhibition of protein synthesis. 6 A new nitrosourea glucoside had activity which was comparable to that of... 

Weinstein JN, Magin RL, Cysyk RL, et al. Treatment of solidL1210 murine tumors with local hyperthermia and temperature sensitive liposomes containing methotrexate. Cancer Res 1980 40 1388-1395. 

During hyperthermia, terms representing the heat input to a specific tissue or whole body must be added to the proper system equation(s). For example, during whole-body or local hyperthermia induced by radiofrequency currents, microwaves, or ultrasound, a heat-generation term is added to the section of the body being heated. During hyperthermia with blood perfusion, the afferent blood temperature is set at a desired value, and the efferent blood is circulated to the central blood pool, or to the extracorporeal device used for heating the blood. Suitable numerical... 

Depending upon the surface area or volume heated, hyperthermia can be divided into three categories (i) local, (ii) regional, and (iii) whole-body. In local hyperthermia, tumor mass and minimum surrounding tissue are heated in regional hyperthermia, usually the limb containing the tumor mass is heated and in whole-body hyperthermia (WBH), the temperature of the host is elevated. 

Intravenous administration of the thermally responsive ELP-rhodamine conjugate resiilted in localized precipitation in tumor tissue heated to 42°C, while no precipitation was observed when a control ELP-rhodamine conjugate, with a Tt of 70°C, was administered. Localized hyperthermia resiilted in a 2-fold increase in intratumoral accumulation... 

Meyer DE, Kong GA, Dewhirst MW, Zalutsky MR, Chilkoti A. Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia. Cancer Res 2001 61 1548-1554. 

Meyer DE. Drug targeting using thermally responsive polymers and local hyperthermia. J Contr Rel 2001 74 213-224. 

Cope DA et al. Enhanced delivery of a monoclonal antibody F(ab )2 fragment to subcutaneous human glioma xenografts using local hyperthermia. Cancer Research 1990 50 1803-1809. 

Olszewski W.L., Engeset A., Jaeger P.M. et al. 1977. Flow and composition of leg lymph in normal men during venous stasis, muscular activity and local hyperthermia. Acta Physiol. Scand. 99 149. 

Griffin, R. J., Ogawa, A., Shakil, A., and Song, C. W., 1998, Local Hyperthermia Treatment of Solid Tumors Interplay Between Hiermal Dose and Physiological Parameters, ASME, HTD—Vol. 362, Advances in Heat and Mass Transfer in Biological Systems, pp. 67-69. 

Song, C. W., 1984, Effect of Local Hyperthermia on Blood Flow and Microenvironment A Review, Cancer Research, 44 4721s-4730s. 

Heat is one of the most efficient weapons to destroy tumor cells. But to induce a moderate heat of 41-47°C for a short duration (5-10 min) in the body without affecting normal tissue is quite difficult. Some of the commonly used heating sources to induce localized hyperthermia in the body are radiofrequency (RF), microwaves, ultrasound, magnetic field, and light [24]. 

Some disease states are associated with local hyperthermia. Alternatively, local increases in body temperature can be induced by exterior means, making temperature-directed drug release another viable triggered release strategy. To that aim, polymers... 

Zhao DL, Wang XX, Zeng XW, Xia QS, Tang JT. Preparation and inductive heating property of Fe304-chitosan composite nanoparticles in an AC magnetic field for localized hyperthermia. J Alloys Compd. 2009 477(l-2) 739 3. 

Fessenden P, Lee ER, Anderson TL, Strohbehn JW, Meyer JL, Samulski TV, Marmor JB (1984) Experience with a multitransducer ultrasound system Iot localized hyperthermia of deep tissues. IEEE Trans Biomed Eng 31 126-135... 

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