Pathological tissues

MA M10 M10.001 Matrix metallopeptidase-1 Drug target for prevention of pathological tissue damage... 

Chen DY, Lan JL, Lin FJ, Hsieh TY. Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still s disease. J Rheumatol 2004 31(11) 2189-2198. 

In patients with cardiac hypertrophy from chronically pressure-loaded human left ventricles due to aortic valve stenosis, a general reduction in gap junction surface area per unit cell volume by about 40% (0.0031 versus 0.0051 pm2/ pm3) has been observed [Peters et al., 1993]. The gap junctions in the pathological tissue were larger than normal. The estimated gap junction content per cell was reduced [Peters et al., 1993]. A reduction by 30% in the gap junction surface per cell was observed [Peters, 1996]. However, the number of intercalated disks per myocyte and the mean density of packing of connexons at freeze-fracture in these hearts remained unchanged as compared to control hearts. 

The target-binding surface of the cell has been well explored with a range of tumor-associated and other antigens, identified, and used for pathological tissue characterizations. 

Oxidative modification of proteins renders them more susceptible to proteolytic attack and enzymic hydrolysis (Wolff et al., 1986 Davies, 1987). Hence, if generation of active oxygen species occurs significantly in vivo, one consequence may be accelerated hydrolysis of damaged proteins. Therefore, radical generation at inappropriate sites may lead to destruction of the protein and pathological tissue degradation. 

The increasing availability of antibodies should facilitate studies into whether or not ET-1 is synthesized and released at or near the site of action and make it possible to determine the levels of endothelin in pathological tissue samples and correlate this to the state of a disease. 

These techniques can be used to achieve a very sharp contrast between various tissues. This permits better differentiation and characterization of normal or pathological tissues, compared with ultrasonography and CT. 

Most examples of cubic membranes in pathological tissue appear in neoplastic and infected cells (Table 7.2). In view of our results, and of the apparent ubiquity and widespread appearance of cubic membranes, a correlation between certain pathological conditions and the expression of cubic membranes deserves serious consideration. It is our opinion that the... 

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