Magnetic hyperthermia

Sonvico F, Mornet S, Vasseur S, Dubernet C, Jaillard D, Degrouard J, Hoebeke J, Duguet E, Colombo P, Couvreur P (2005) Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators synthesis, physicochemical characterization, and in vitro experiments. Bioconjugate Chemistry 16 1181-1188. 

The first clinical human trials using magnetic hyperthermia were reported by Liibbe, et al. [70, 129, 137, 190] who used 100-nm starch-coated iron-oxide particles bound with epirubicin for treatment of advanced solid cancers. Jordan recently reported positive results from ongoing trials of advanced cancer patients who received magnetic nanoparticle hyperthermia in conjunction with conformal external beam radiation therapy [191]. The therapy was well tolerated by the patients and significant increases in the length and quality of life were observed. 

Kita E, Oda T, Kayano T, Sato S, Minagawa M, Yanagihara H, Kishimoto M, Mitsu-mata C, Hashimoto S, Yamada K, Ohkohchi N. Ferromagnetic nanoparticles for magnetic hyperthermia and thermoablation therapy. Journal of Physics D Applied Physics. 2010 43 474011(1)-474011(9). DOI 10.1088/0022-3727/43/47/474011. 

Carrey J, Mehdaoui B, Respaud M. Simple models for dynamic hysteresis loop calculations of magnetic single-domain nanoparticles application to magnetic hyperthermia optimization. Journal of Applied Physics. 2011 109 083921(1)—083921 (17). DOI 10.1063/1.3551582. 

Dong-Hyun Kim, Kyoxmg-Nam Kim, Kwang-Mahn Kim, Yong-Keun Lee (2009). Targeting to carcinoma cells with chitosan- and starch-coated magnetic nanoparticles for magnetic hyperthermia. Journal of Biomedical Materials Research Part A, Volume 88. Issue 1, pp 1-11. 

Puig J et al (2012) Superparamagnetic nanocomposites based on the dispersion of oleic acid-stabilized magnetite nanoparticles in a diglycidylether of bisphenol a-based epoxy matrix magnetic hyperthermia and shape memory. J Phys Chem C 116(24) 13421-13428... 

Fortin J-P, Wilhelm C, Servais J, Menager C, Bacri J-C and Gazeau F (2007) Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia, J Am Chem Soc 129 2628-2635. 

Pardoe, H. Clark, P.R. St Pierre, T.G. Moroz, P. Jones, S.K. (2003), A magnetic resonance imaging based method for measurement of tissue iron concentration in liver arterially embolized with ferrimagnetic particles designed for magnetic hyperthermia treatment of tumors. Magn. Reson. Imaging, 21 483-488. 

Andra W (1998) Magnetic Hyperthermia. In Andra W, Nowak H (eds) Magnetism in Medicine. 

Purushotham and Ramanujan (2010) presented a case study in which iron oxide (Fej04) mNPs were coated with a thermo-sensitive polymer, PNIPAM, and used for simultaneous magnetic hyperthermia and controlled... 

It should be noted that the Neel-Brown relaxation model, although widely employed throughout the literature for predicting and interpreting dilferent parameters of interest in colloids for magnetic hyperthermia such as optimum particle size, frequency or field amplitude, has been criticised due to the disagreements found in both qualitative and quantitative analyses. Some of these will be commented on in Sections 2.4.1 and 2.4.2. 

Optimum particle size. The optimum particle size for magnetic hyperthermia is still a matter of debate mainly due to the lack of conclusive data to date comparing the predicted and in vivo performance of magnetic nanoparticles for a wide range of tumours. Nevertheless it is physically reasonable to assume that the role of size and size distribution on the heating properties of particles will be both significant and pertinent. 

The glioblastoma multiforme (GBM) is the most common and deadly type of brain tumour, with a median life expectancy of twelve months after diagnosis. The data from a recent non-randomised phase II clinical trial by the team of Andreas Jordan have shown improvements in survival times after a combined treatment of magnetic hyperthermia with 12 nm amino-silane-coated magnetite nanoparticles and fractioned stereotactic radiotherapy. After going through both the corresponding feasibility and... 

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