Cancer broccoli

Indoles Inhibit estrogen, which stimulates some cancers Broccoli, cabbage, cauliflower, mustard... 

SHAPIRO T A, FAHEY J w, WADE K L, STEPHENSON K K and TALALAY p (2001) Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts metabolism and excretion in humans . Cancer Epidemiol Biomarkers Prev, 10 501-8. 

LIN H J, PROBST-HENSCH N M, LOUIE A D, KAU I H, WITTE J S, INGLES S A, FRANKL H D, LEE E R and HAILE R w (1998) Glutathione transferase null genotype, broccoli and lower prevalence of colorectal adenomas . Cancer Epidemiol Biomarkers Prev, 7 647-52. 

Canene-Adams, K., B. L. Lindshield, S. Wang et al. 2007. Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas. Cancer Res 67(2) 836-843. 

The present results also point to differences between the mammary tumor model and the ACT model for evaluating the potential cancer protective effects of Se in broccoli. A previous study (17) showed that high-Se broccoli florets decreased the number of DMH-induced ACT. Similarly, in the present study high-Se broccoli sprouts decreased DMH-induced ACT, but low-Se broccoli sprouts alone did not have any effect (Table 3). In the mammary tumor model, however, broccoli alone, similar to garlic alone (3), reduced the number of tumors (Table 1). This contrasting effect could be the result of a difference between tumor and preneoplastic lesion models, a difference between carcinogens, or a difference between mammary and colonic tissues. 

Recoupling Cancer-Protective Properties of Angle-Spinning NMR High-Selenium Broccoli A Class II Aldolase MimH ... 

Ambrosone, C.B., McCann, S.E., Freudenheim, J.L., Marshall, J.R., Zhang, Y., and Shields, P.G., Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype, J. Nutr., 134, 1134, 2004. 

And to add some fun to this process, the indoles found in cruciferous vegetables such as broccoli, cabbage, and brussel sprouts are also inducers. In fact. Dr. Bruce Ames, UC Berkeley, a prominent voice in the great cancer debate, points out that there are positive and negative aspects to induction. That caused but natural foods such as broccoli may have a positive effect in ridding the body of cancer-causing xenobiotics. 

Direct proof regarding whether antimutagenic or anticarcinogenic effects also occur in humans under normal dietary conditions can only be obtained from studies with humans. Indeed, epidemiological studies indicate that consumption of fruits and vegetables is inversely associated with the risk of cancer. In particular, brassica vegetables such as cabbage, brussels sprouts, and broccoli have been attributed with beneficial health effects in humans. 

Similarly, it has been shown that consumption of cruciferous vegetables is associated with a lower incidence of cancers. Induction of phase II enzymes such as the glutathione S-transferase (GST) and quinone reductase (QR) have been demonstrated in broccoli, cabbage, and brussel sprouts. Many natural isothiocyanates derived from cruciferous vegetables and some fruits have been shown to cause induction of phase II enzymes in cultured cells and rodents. 

J. W. Finley, C. D. Davis, Y. Feng, Selenium from high-selenium broccoli is protective against colon cancer, J. Nutr., 130 (2000), 2384D2389. 

The 5-glycoside in broccoli and brussels sprouts that protects from cancer is somewhat similar but has one more carbon atom in the chain and contains a sulfoxide group as well. Hydrolysis of the S-glycoside is followed by the same rearrangement, producing a molecule called sulforaphane. Sulforaphane... 

There are no reported feeding studies showing protection by broccoli against chemically induced cancers in animal models. However, there is an abundant... 

An enzyme involved in cell cycle control has been identified as the target of a compound supplied by broccoli, cabbage, and Brussels sprouts. One of the glucosinolates of these foods is the source of a chemical called indole 3-carbinol. Indole-3-carbinol enters the cell and influences the activity of a spixiat protein kinase that is used to control the cell cycle. The chemical prevents the synthesis of the enzyme, and thus reduces its activity. The action of this protein kinase (cyclin-dependent protein kinase 6) normally functions to make the cell embark on the G phase of the cell cycle, and thus to stimulate progression through the cell cycle. The chronic decrease in activity of this protein kinase serves to prevent cell division, but also prevents spontaneous cancers. The effect of mdoJe-3-carbinol has been shown to occur in cultured cells, as well as in animals (Cover ef o/ 1998). 

Broccoli and other cruciferous vegetables Sulforaphane Reduce risk for cancer... 

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