Calcium/calmodulin-dependent protein kinase type

This enzyme [EC 2.7.1.123], also referred to as calcium/ calmodulin-dependent protein kinase type II, and micro-tubule-associated protein MAP2 kinase, catalyzes the reaction of ATP with a protein to produce ADP and an 0-phosphoprotein. The enzyme requires calcium ions and calmodulin. Proteins that can serve as substrates include vimentin, synapsin, glycogen synthase, the myosin light-chains, and the microtubule-associated tau protein. This enzyme is distinct from myosin light-chain kinase [EC 2.7.1.117], caldesmon kinase [EC 2.7.1.120], and tau-protein kinase [EC 2.7.1.135]. 

Matthews, R. P., Guthrie, C. R., Wailes, L. M., Zhao, X., Means, A. R. and McKnight, G. S., 1994, Calcium/calmodulin-dependent protein kinase types II and TV differentially regulate CREB-dependent gene expression., Mol Cell Biol, 14, pp 6107-6116. 

See, V., Boutillier, A. L., Bito, H. and Loeffler, J. P., 2001, Calcium/calmodulin-dependent protein kinase type TV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons, Faseb J, 15, pp 134-144. 

Murray, K.D., Gall, C.M., Jones, E.G. and Isackson, P.J. (1994) Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer s disease. Neuroscience 60 37—48. 

Ho, M.W., Kaetzel, M. A., Armstrong, D.L. and Shears, S.B., 2001, Regulation of a human chloride channel, a paradigm for integrating input from calcium, type II calmodulin-dependent protein kinase, and inositol 3,4,5,6-tetrakisphosphate. J. Biol. Chem. 276 18673-18680. 

With its multiple second messengers and protein kinases, the phosphoinositide signaling pathway is much more complex than the cAMP pathway. For example, different cell types may contain one or more specialized calcium- and calmodulin-dependent kinases with limited substrate specificity (eg, myosin light-chain kinase) in addition to a general calcium- and calmodulin-... 

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