Micro-tubules

The mode of action has not yet been elucidated but the manufacturer states that it probably behaves like the herbicide triflurolin and its congeners. These materials inhibit cell division by binding to tubuHn thereby internipting micro-tubule development. This, in turn, stops spindle fiber formation essential to mitosis and cell division. Experiments with C-labeled Prime+ show that it is acutely toxic to fish with estimated LC q (96 h) of less than 100 ppb for rainbow trout and bluegiU. sunfish. However, channel catfish did not exhibit any toxic response at the maximum attainable water concentration (10). 

Apodaca G. Endocytic traffic in polarized epithelial cells role of the actin and micro tubule cytoskeleton. Traffic 2001 2(3) 149-159. 

This enzyme [EC 2.7.1.123], also referred to as calcium/ calmodulin-dependent protein kinase type II, and micro-tubule-associated protein MAP2 kinase, catalyzes the reaction of ATP with a protein to produce ADP and an 0-phosphoprotein. The enzyme requires calcium ions and calmodulin. Proteins that can serve as substrates include vimentin, synapsin, glycogen synthase, the myosin light-chains, and the microtubule-associated tau protein. This enzyme is distinct from myosin light-chain kinase [EC 2.7.1.117], caldesmon kinase [EC 2.7.1.120], and tau-protein kinase [EC 2.7.1.135]. 

Bui goyne RD, Cumming R (1984) Ontogeny of micro tubule-associated protein 2 in rat cerebellum Differendal expression of tire doublet polypepddes. Neuroscience 11 156-167. 

Huber G, Matus A (1984) Immurrocytochemical localizadorr of micro tubule-associated proteirr 1 irr rat cerebellum usirrg morro-clorral arrtibodies. J Cell Biol 98 777-781. 

Matus A, Bernhardt R, Hugh-Jorres T (1981) High molecular- weiglrt micro tubule-associated proteirrs ar-e prefererr dally associated widr derrdridc microtubules nr brairr. Proc Natl Acad Sci USA 78 3010-3014. 

Lewy body Intracytoplasmic neuronal inclusions which are intensely eosinophilic under routine haematoxylineosin stain. Immuocytochemically, Lewy bodies share epitopes with phos-phorylated and non-phosphorylated a-synclein, neurofilament subunits, tubulin, micro tubule-associated protein 1 and 2, and... 

J. Park, J. Kim, and Y. Son, Conducting polymer micro-tubules hosting electroactive species without guest modification, Synth. Met., 156(9-10), 714-720 (2006). 

Lin S, Fang K, Hashimoto M, Nakanishi K, Ojima I (2000) Design and Synthesis of a Novel Photoaffinity Taxoid as a Potential Probe for the Study of Paclitaxel-micro-tubules Interactions. Tetrahedron Lett 41 4287... 

Figure 7. SEM image of as-grown aligned polythiophene micro-tubules and the corresponding photograph of a water droplet on the surface (inset). Reproduced with permission from [42]. Copyright 2003 the Royal Society of Chemistry.

Belotti D, Vergani V, Drudis T, Borsotti P, Pitelli MR, Viale G, Giavazzi R, Taraboletti G. The micro-tubule-affecting drug paclitaxel has anti-angiogenic activity. Clin Cancer Res 1996 2(11) 1843-9. 

Pendimethalin Dinitro-anilines Micro-mbule assembly Micro-tubule assembly inhibition 1976 Pre- and postemergence Soybean, maize Grasses, bioadleaf weeds, 560-2250... 

Trifluralin Dinitro-aniline Micro-tubule assembly inhibition Micro-tubule assembly inhibition 1964 Pre- emergence Soybean, cotton Grasses, 580-1100... 

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