CA1 pyramidal cells

Ameri A. Effects of the Aconitum alkaloid songorine on synaptic transmission and paired-pulse facilitation of CA1 pyramidal cells in rat hippocampal slices. Br J Pharmacol 1998 125 461—468. 

Alger, B. E., and Nicoll, R. A. (1980) Epileptiform burst afterhyperpolarization Calcium-dependent potassium potential in hippocampal CA1 pyramidal cells. Science, 210 1122-1124. 

The inset in A is a representative evoked potential recorded from the CA1 pyramidal cell layer. Calibration hards vertical 2 mV, horizontal 10 msec. The population spike amplitude was defined as an average of the amplitude from the first positive peak 1 to the succeeding negative peak 2 and the amplitude from die negative peak 2 to the second positive peak 3. A Time-course of potentiation induced by strong tetanic stimulation in the control slices (O, n=23) and in the slices treated with 30% of ethanol (IS ml/kg) (, n=27 ) and in the slices treated with 30% of ethanol (IS ml/kg) and 20 mg/kg crocin ( A, n-7). (1) and (2) indicated 30% ethanol of IS ml/kg and 10 ml/kg, respectively. Ethanol or crocin was added in the perfusing ACSF from 15 or 20 min, respectively, before tetanic stimulation. The ordinate indicates the population spike amplitude expressed as a percentage of the baseline values immediately before tetanic stimulation. 

Gereau, R.W. 4th and Conn, P.J. Roles of specific metabotropic glutamate receptor subtypes in regulation of hippocampal CA1 pyramidal cell excitability, J Neurophysiol. 1995, 74, 122-129. 

Seidenman K. J., Steinberg J. P., Huganir R., and Malinow R. (2003). Glutamate receptor subunit 2 Serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells. J. Neurosci. 23 9220-9228. 

Jarolimek W, Misgeld U (1997) GABAB receptor-mediated inhibition of tetrodotoxin-resistant GABA release in rodent hippocampal CA1 pyramidal cells. J Neurosci 17 1025-32 Jeong SW, Ikeda SR (2000a) Effect of G protein heterotrimer composition on coupling of neurotransmitter receptors to N-type Ca(2+) channel modulation in sympathetic neurons. Proc Natl Acad Sci USA 97 907-12... 

The firing rate of hippocampal CA1 pyramidal cells is known to depend on spatial location, that is, contextual environment information related to exploration behavior is encoded by cell activity (Hollup et al., 2001 Thompson and Best, 1990). In the present study, the population spike amplitude (PSA), measured with simultaneous determination of locomotor activity, in the CA1 field evoked by Schaffer collaterals stimulation was slightly decreased during exposure to the open field (Fig. 1). However, no significant difference in changes of synaptic transmission in the CA1 field was observed between the FS groups and non-FS controls (Koseki et al., 2007). 

CA1 pyramidal cell GABAa CA1 pyramidal cell GABAa... 

By in situ hybridization histochemistry, 5-HT5B receptors have been shown to be predominantly expressed in the habenular nuclei, hippocampal CA1 pyramidal cells and inferior olivary nucleus of the rat, and at weaker levels in the entorhinal cortex and NRD (210). The 5-HT5B receptor mRNA has recently been shown to be coexpressed with the plasma membrane 5-HT transporter in the NRD (217), strongly suggesting an autoreceptor as well as heteroreceptor role for 5-HT5B as well as 5-HT5A receptors. 

HT4 Receptor-Mediated Depolarization of CA1 Pyramidal Cells Activation of 5-HT4 receptors depolarizes pyramidal cells of the CA1 region of the hippocampus (45,46) through a mechanism that involves cAMP but is... 

Arrigoni E, Greene RW. 2004. Schaffer collateral and perforant path inputs activate subtypes of NMDA receptors on the same CA1 pyramidal cell. J Pharmacol 142 317-322. 

Hillman KL, Doze VA, Porter JE. 2005. Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus. J Pharmacol Exp Ther 314 561-567. 

Mannaioni G, Marino MJ, Valenti O, Traynelis SF, Conn PJ. 2001. Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. J Neurosci 21 ... 

FG-Loop (FGL), a neural cell adhesion molecule-derived peptide that corresponds to its second fibronectin type III module, has been shown to provide neuroprotection against a range of cellular insults. FGL improves memory and alleviates the deleterious effects on CA1 pyramidal cells induced by AP25-35 injection. These effects might be due to inactivation of GSK3P [597]. 

Corbett NJ, Gabbott PL, Klementiev B, Davies HA, Colyer FM, Novikova T et al (2013) Amyloid-Beta induced CA1 pyramidal cell loss in young adult rats is alleviated by systemic treatment with FGL, a neural cell adhesion molecule-derived mimetic peptide. PLoS One 8 e71479. doi 10.1371/journal. pone.0071479... 

Nadler and Cuthbertson (1980) have examined the effects of prior transection of hippocampal pathways on the pattern of neural vulnerability to kainic acid. Lesion of the entorhinal- (Kohler et al, 1978) or septo-hippocampal pathways protects dentate granule cells and most of the CA1 pyramidal cells from the neurotoxic effects of kainate injected into the hippocampus three days after the lesion. When both pathways are interrupted, the CA2 pyramidal cells also survive. However, disruption of the mossy fiber or commisural innervation to the hippocampus does not attenuate kainate s neurotoxicity on the hippocampal pyramidal cells. Notably, septal lesions that ablate the cell bodies of origin of the cholinergic... 

Sahara, Y., Robinson, H.P., Miwa, A., and Kawai, N., 1991,A Voltage-clamp Study of the Effects of Joro Spider Toxin and Zic on Excitatory synaptic Transmission in CA1 Pyramidal Cells of the Quinea Pig Hippocampal Slice, In Neurosci.Res., 10, 200-210. 

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