Joro spider toxin

A number of invertebrate polyamine toxins have recently been shown to be open channel blockers of glutamate receptors initially at the neuromuscular junction of locusts [54] and recently on central mammalian neurones [54-57], These toxins include argiotoxin 636, Joro spider toxin and philanthotoxin. Although these polyamine toxins block NMDA receptors at least in some preparations, in others they also block responses mediated by AMPA receptors more selectively [58-60]. 

Barslund AF, Poulsen MH, Bach TB, Lucas S, Kristensen AS, Str0mgaard K (2010) Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata. J Nat Prod 74 483-486... 

Sahara, Y., Robinson, H.P., Miwa, A., and Kawai, N., 1991,A Voltage-clamp Study of the Effects of Joro Spider Toxin and Zic on Excitatory synaptic Transmission in CA1 Pyramidal Cells of the Quinea Pig Hippocampal Slice, In Neurosci.Res., 10, 200-210. 

JSTX. A group of arylamide toxins from the venom glands of the Japanese joro spider, Nephila clavate, and related species. Blocks glutamate receptors in both Crustacea and mammalia. 

Nishimaru, T Sano, M. Yamaguchi, Y Wakamiya, T. Syntheses and biological activities of fluorescent-labeled analogs of acylpolyamine toxin NPTX-594 isolated from the venom of Madagascar Joro spider. Bioorg. Med. Chem. 2009, 17, 57-63. 

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