Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Tetrodotoxin TTX resistibility

Other subtypes of Na+ channels such as the tetrodotoxin (TTX)-resistant Na+ channels are also expressed by airway afferent nerves. Capsaicin-sensitive neurones are sensitized by inflammatory mediators, such as PGE2, an effect partly mediated by an increase in TTX-resistant Na+ currents (Kwong and Lee 2005). These neurones are inactivated in the normal airways, but are recruited in inflamed airways to contribute to cough sensitization (Mazzone et al. 2005). Therefore, selective inhibitors of TTX-resistant Na+ channels may be useful as cough suppressants in chronic cough. [Pg.359]

Gold MS, Reichling DB, Shuster MJ, Levine JD 1996 Hyperalgesic agents increase a tetrodotoxin-resistant a current in nociceptors. Proc Natl Acad Sci LISA 93 1108-1112 Gold MS, Levine JD, Correa AM 1998 Modulation of TTX-R Ix i by PKC and PKA and their... [Pg.153]

See other pages where Tetrodotoxin TTX resistibility is mentioned: [Pg.290]    [Pg.56]    [Pg.371]    [Pg.113]    [Pg.25]    [Pg.290]    [Pg.56]    [Pg.371]    [Pg.113]    [Pg.25]    [Pg.930]    [Pg.565]    [Pg.301]    [Pg.285]    [Pg.171]    [Pg.467]    [Pg.620]    [Pg.289]    [Pg.144]    [Pg.144]    [Pg.144]    [Pg.144]    [Pg.1043]    [Pg.3996]   
See also in sourсe #XX -- [ Pg.199 ]



SEARCH



© 2024 chempedia.info