C57BL/6J mice

Murante, F. and Gasiewicz, T., Hemopoietic progenitor cells are sensitive targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57Bl/6j mice, Toxicol. Sci., 54, 374, 2000. 

Tuite, A., et al., Genetic control of susceptibility to Candida albicans in susceptible A/J and resistant C57BL/6J mice, Genes Immun. 6, 8, 672, 2005. 

Fowles, J. R. et al., Immunologic and endocrine effects of the flame retardant pentabro-modiphenyl ether (DE-71) in C57BL/6J mice, Toxicology, 86, 49, 1994. 

Johnston, M.C., Sulik, K.K. and Dudley, K.H. (1979). Genetic and metabolic studies of the differential sensitivity of A/J and C57BL/6J mice to phenytoin ( Dilantin )-induced cleft lip. Teratology 19 33 A. 

Tael gene deletion C57BL/6J mice Decreased BUkei-Gorzo et al. 2002... 

Moochhala. 1 Methyl 4 phenyh 1,2,3, 6 tetrahydropyridine induced neuro-toxicity partial protection against striato-nigral dopamine depletion in C57BL/6J mice by cigarette smoke ex-posure and by beta-naphthoflavone-pretreatment. Neurosci Lett 1991 127(2) 247-250. 

Snyder, C.A., Goldstein, B.D., Sellakumar, A., Bromberg, L, Laskin, S., AND Albert, R.E. (1980). The inhalation toxicity of benzene incidence of hematopoietic neoplasm and hematotoxicity in AKR/J and C57BL/6J mice, Tfaxicol. Appl. Pharmacol 54,323. 

Hanigan MH, Winkler ML, Drinkwater NR. 1993. Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice. Carcinogenesis 14(5) 1035-1040. 

Hydroquinone decreased interleukin (IL)-l secretion and protein and RNA synthesis of isolated human peripheral blood monocytes induced by Escherichia coli lipopoly-saccharide at micromolar concentrations (Carbonnelle etal., 1995). Hydroquinone (4 pmol/L) inhibited the growth of bone marrow cells from female C57BL/6 x DBA/2 mice (Seidel et al., 1991) and from male Swiss Webster and C57BL/6J mice (10 pmol/L) (Neun et al., 1992). Hydroquinone (50, 75 or 100 mg/kg bw, single intraperitoneal admi-... 

Webster and C57BL/6J mice was reduced upon exposure to 1,4-benzoquinone in a dose-... 

Lopez-Briones, S., Soloski, M.J., Bojalil, R., Fragoso, G. and Sciutto, E. (2001) CD4+TCRa(iT cells are critically involved in the control of experimental murine cysticercosis in C57BL/6J mice. Parasitology... 

Meerlo P, Easton A, Bergmann BM, Turek FW. Restraint increases prolactin and REM sleep in C57BL/6J mice but not in BALB/cJ mice. Am J Physiol 2001 28LR846-R854. 

Nelson JF, Gosden RG, Felicio LS. Effect of dietary restriction on estrous cyclicity and follicular reserves in aging C57BL/6J mice. Biol Reprod 1985 32 515-522. 

To mimic late-stage T2DM symptoms observed in humans, DIO-C57BL/6J mice can be treated with low doses of strepto-zotocin (STZ). While mice treated with high doses of STZ are considered a model of type I diabetes, when the drug is administered at low doses to DIO mice, it mimics the partial loss of islet cells in the advanced stages of T2DM (9). 

Consider strain differences in this paradigm. Some stressors may not affect all strains homogenously, and similarly, some models of depression may not accurately reflect depression in specific strains. For example, C57BL/6J mice are not sensitive to CMS affects on coat state (38). 

Acute effects of 2,3,7,8-TCDD on thyroid function have been also reported in mice. In contrast with observations in rats, in which 2,3,7,8-TCDD appears to have independent effects on T4 and T3 levels, serum T4 and T3 levels were decreased in a dose-dependent fashion in male C57BL/6J mice 8 days after a single gavage dose of 0.03-235 g 2,3,7,8-TCDD/kg (Weber et al. 1995). A similar effect was observed in male DBA/2J mice treated with a single dose of 1-3,295 g/kg. In C57BL/6J mice, maximum depression of thyroid hormones (35% of controls) was achieved with a dose of 133 g/kg. In male DBA/2J mice, maximum reductions in T3 and T4 levels (40 and 20% of controls, respectively) were attained with the highest dose level (Weber et al. 1995). It should be noted that the Weber et al. (1995) study did not include statistical analysis of the results. 

Leung et al. (1988) varied the fat content parameter in the C57BL/6J mice from 3 to 12% of body weight. The rationale was that the difference in hepatic concentration may have been due to greater capacity of the DBA/2J mouse to sequester the highly lipophilic 2,3,7,8-TCDD in adipose tissue. However, the results showed that 2,3,7,8-TCDD concentration in the liver was relatively insensitive to body fat content, indicating that this was not an important factor influencing the disposition of 2,3,7,8-TCDD in... 

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