Hematopoietic neoplasms

Pinkus, G. S. and Kurtin, P. J. (1985) Epithelial membrane antigen—A diagnostic discriminant in surgical pathology immunohistochemical profile in epithelial, mesenchymal, and hematopoietic neoplasms using paraffin sections and monoclonal antibodies. Hum. Pathol. 16, 929-940. 

Some epidemiological studies have suggested increased risks for lymphatic and hematopoietic neoplasms. However, the risks are generally small, statistically unstable, and often based on subgroup analyses. The possibility that the observations are the results of confounding by other occupational exposures cannot be ruled out. ... 

In particular, since tumors are in part characterized by abnormal accumulation of malignant cells which survive for long time by escaping apoptosis, recent attention has been focused on the role of apoptosis in hematopoietic neoplasms. 

Snyder, C.A., Goldstein, B.D., Sellakumar, A., Bromberg, L, Laskin, S., AND Albert, R.E. (1980). The inhalation toxicity of benzene incidence of hematopoietic neoplasm and hematotoxicity in AKR/J and C57BL/6J mice, Tfaxicol. Appl. Pharmacol 54,323. 

K21. Knowles, D. M., Murray, A., and Chadburn, A., Immunophenotypic markers useful in the diagnosis and classification of hematopoietic neoplasms. In Neoplastic Hematopathology (D. M. Knowles, ed.), pp. 93-226. Lippincott Williams Wilkins, Philadelphia, PA, 2001. 

Snyder CA, Goldstein BD, Sellakumar AR, et al. 1980. The inhalation toxicology of benzene Incidence of hematopoietic neoplasms and hematotoxicity in AKR/J and C57BL/6J mice. Toxicol Appl Pharmacol 54 323-331. 

The hematopoietic neoplasms are a diverse group of malignancies tliat traditionally have been diagnosed by use of a variety of ancillary techniques. Important advances over the last few decades have elucidated the biological bases for the development of these diseases. The hematopoietic malignancies include the lymphomas, leukemias, and plasma cell dyscrasias. These diseases represent neoplastic proliferations of the hematopoietic system and are characteri2ed by monoclonality, clonal progression, clonal dominance, and suppression of normal clones. 

Chapter 39 Molecular Genetics and Diagnosis of Hematopoietic Neoplasms... 

Hematopoietic neoplasms only rarely present as soft tissue masses, and this phenomenon is particularly unusual in pediatric patients in whom other forms of small round cell tumors are most common. Because of the virtually ubiquitous presence of CD45 in hematopoietic cells and its extremely high degree of specificity, that marker is very valuable in this context. Not all antibodies raised against CD45 identify determinants that survive routine tissue processing, but the monoclonal antibody cocktail PD7/26 2B11 (see Table 4.3) is indeed active in paraffin sections. 

Al Saati T, Caveriviere P, Gorguet B, et al. Epithelial membrane antigen in hematopoietic neoplasms. Hum Pathol. 1986 17 533-534. 

Two other hematopoietic neoplasms that may present in the mediastinum are granulocytic sarcoma (extramedullary myelogenous leukemia Fig. 11.28) ... 

FIGURE 11.25 Algorithm for Immunohistologic evaluation of hematopoietic neoplasms of the mediastinum. 

Kurtin PJ, Pinkus GS. Leukocyte common antigen—a diagnostic discriminant between hematopoietic and non-hematopoietic neoplasms in paraffin sections using monoclonal antihodies cottelation with immunologic smdies and ultrastrucmral localization. Hum Pathol. 1985 16 353-365. 

Virtually any type of tumor, including soft tissue tumors and hematopoietic neoplasms such as lymphoma and leukemia, can involve the ovaries, either primarily or as metastases from a distant site. Many of these have specific immunohistochemical features, as detailed elsewhere in this book, which can be used to assist in their diagnosis. 

Howard EB, Clarke WJ. 1970. Induction of hematopoietic neoplasms in miniature swine by chronic feeding of strontium-90. J Natl Cancer Inst 44(1) 21-38. 

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