Bone morphogenic proteins

Collagen fibrils provide the scaffolding for formation of bone, whose composition is considered on pp. 440-443. Bone develops under the influence of bone morphogenic proteins BMP-2 to BMP-7.413-415 Most of these are cytokines of the TGF-(f family. Noggin... [Pg.1902]

Friedlaender G. E., et al. (1999) Osteogenic protein-1 (bone morphogenic protein-7) in the treatment of tibial nonunions. J. Bone Joint Surg. 83-A, S1-151-S1-158. [Pg.4044]

Zeisberg M, Shah AA, and Kalluri R. Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney.The Journal of Biological Chemistry 280 8094-8100, 2005. [Pg.82]

Polyanions have yielded different effects on the solubility of proteins with high pi. Polyanions such as sulfated polysaccharides have limited effects on the solubility of basic fibroblast growth factor, a protein with a high pi, since specific interactions yield reversible precipitates containing bioactive and native protein (Sommer and Rifkin, 1989 Shahrokh et ah, 1994). By contrast, sulfated polysaccharides were most effective in enhancing the solubility of bone morphogenic protein, a very low solubility, high pi protein (Zhu, 1999). [Pg.350]

Bone morphogenic proteins (BMPs) represent another interesting class of biophar-maceutical (Table 9). As their name suggests, these proteins can promote the deposition and growth of new bone, and are... [Pg.40]

It should be noted that quite recently, the first two agents that can effect bone growth have appeared on the market Novos (bone morphogenic protein 7) in Australia in 2001 and InFuse (bone mor-... [Pg.464]

USA dibotermin alfa protein InFuse InductOS Recombinant human bone morphogenic protein-2 expressed in CHO cells Bone fusion... [Pg.468]

Australia OP-1 protein Novos OP-1 implant Recombinant human osteogenic protein-1, or bone morphogenic protein 7 expressed in CHO cells Bone morphogenesis... [Pg.468]

Bone marrow transplant (BMT) 1757 Bone morphogenic protein (BMP) 294 Bongard problem 1773 Boost Plus 1454... [Pg.1846]

Michalzik et al. [152] developed an immimosensor for the detection of bone morphogenic protein-2. 20 MHz crystals were incorporated to increase the potential sensitivity of the sensor, which had a limit of detection of... [Pg.272]

Abbreviations BMP bone morphogenic protein, CD cluster of differentiation,... [Pg.3]

Growth factors bind to receptors on the cell surface and subsequently activate cellular proliferation or differentiation. Many growth factors stimulate cellular division in numerous cell type, whereas others are specific to particular cell types. They often promote cell differentiation and maturation, whereas varies between growth factors. For example, bone morphogenic proteins stimulate bone cell differentiation, whereas vascular endothelial growth factors stimulate blood vessel differentiation. [Pg.1198]

The hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, otherwise known as the statins, have been found to increase bone formation via enhanced activity of the bone morphogenic protein 2 (BMP-2) gene. This gene increases osteoblast differentiation. In addition, by inhibiting HMG-CoA reductase, the statins not only prevent the biosynthesis of cholesterol but also prevent the formation of compounds associated with osteoclast activation (45). Unfortunately, clinical data... [Pg.1424]

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