Morphogens

Diacetylphloroglucinol and its homologues have been prepared and found to be inhibitors of the herpes vims (188). Syzygiol (50), a skin tumor promotion inhibitor, has been prepared from phloroglucinol (189). The first natural morphogen (cell-differentiation agent) (51) has also been identified as a phloroglucinol derivative (190). 

Transforming growth factor-beta (TGF- 3) proteins are multifunctional morphogens that control cell proliferation, differentiation and apoptosis, as well as cell migration and immune surveillance. TGF-(3 acts as a tumor suppressor, but can also act as a tumor promoter in... 

Monophasic Preparations Monoxide Mood Disorders Mood Elevators Mood-stabilising Drugs Morbus Alzheimer Morphogens Morpholines Motilin... 

Hornung G, Berkowitz B, Barkai N (2005) Morphogen gradient formation in a complex environment An anomalous diffusion model. Phys Rev E 72,041916, DOl 10.1103/PhysRev E.72.041916... 

Flocculins and especially Flo 11 are responsible for morphogenic phenomena such as pseudohyphal growth and biofilm formation in yeast. Biofilm formation is an adhesive phenomenon akin to flocculation. The majority of bacteria exist in highly organized natural biofilm populations rather than in free floating cultures. Within the biofilm, bacteria display coordinated behavior. They form structures, release toxins or emit light. They, sometimes, differentiate to form physiologically defined... 

Kodani S, Hudson ME, DurrantMC, Buttner MJ.NodweUJR, Willey JM, The SapB morphogen is a lantibiotic-fike peptide derived from the product of the... 

During CNS patterning, cells reciprocally coordinate their replication rate, fate, and relative position. These interactions are mediated by direct cell-to-cell contacts, by the local action of secreted polypeptides called morphogens, and by hormonal influences from the macroenvironment. 

Morphogens are form-generating substances, whose configuration within a tissue prefigures the pattern (Meinhardt, 1983). These substances set up an extracellular concentration gradient, which in turns orchestrates a coherent set of cellular behaviors that will eventually result in the proportionate growth of an or-... 

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