Blastogenesis

DiMolfetto-Landon, L. et al., Blastogenesis and interleukin-2 receptor expression assays in the harbor seal (Phoca vitulina), J. Wildlife. Dis., 31, 150, 1995. 

Gifford R, Schmidke J Cimetidine-induced augmentation of human lymphocyte blastogenesis comparison with levamisole in mitogen stimulation. Surg Forum 1979 30 113-115. 

Holt, P. G., Warner, L. A., and Mayrhofer, G. (1981). Macrophages as effector of T suppression T-lymphocyte-dependent macrophage-mediated suppression of mitogen-induced blastogenesis in the rat. Cell. Immunol. 63, 57-70. 

C. Babiuk, et al., Induction of ethylenediamine hypersensitivity in the guinea pig and the development of ELISA and lymphocyte blastogenesis techniques for its characterization. Fundam. Appl. Toxicol. 9 623-634, 1987. 

Torre, P.M. and Oliver, S.P. 1989a. Inhibition of bovine peripheral blood mononuclear cell blastogenesis by fractionated mammary secretion. Comp. Biochem. Physiol. B 92, 157-165. 

C57BI/6J) 6 hr/d lymphocytes and mitogen-induced blastogenesis of femoral T and B-lymphocytes) ... 

Animal studies support the observations made in humans and show that benzene affects humoral and cellular immunity. A decrease in spleen weight was observed in mice after acute-duration exposure to benzene at 25 ppm, 6 hours per day for 5 days, the same dose levels at which a decrease in circulating leukocytes was observed (Wells and Nerland 1991). Benzene decreases the formation of the B-lymphocytes that produce the serum immunoglobulins or antibodies. Exposure to benzene at 10 ppm and above for 6 days decreased the ability of bone marrow cells to produce mature B-lymphocytes in C57BL/6 mice (Rozen et al. 1984). The spleen was also inhibited from forming mature T-lymphocytes at exposure levels of 31 ppm and above. Mitogen-induced blastogenesis of B- and T-lymphocytes was depressed at 10 ppm and above. Peripheral lymphocyte counts were depressed at all levels, whereas erythrocyte counts were depressed only at 100 and 300 ppm. This study is the basis for the acute inhalation MRL of 0.05 ppm (see footnote to Table 2-1 and Appendix A). 

Rozen MG, Snyder CA, Albert RE. 1984. Depression in B- and T-lymphocytc mitogen-induced blastogenesis in mice exposed to low concentrations of benzene. Toxicol Lett 20 343-349. 

In vitro blastogenesis of his peripheral blood lymphocytes was strongly enhanced by piperacillin and tosufloxacin, and they generated a large amount of interleukin-5. 

Acute radiation dose Blastogenesis (up to 2 weeks) to the embryo/fetus... 

Kramer, T.R., Schoene, N., Douglass, L.W., Judd, J.T., Ballard-Barbash, R., Taylor, P.R., Bhagavan, H.N., and Nair, P.P. 1991. Increased vitamin E intake restores fish-oil-induced suppressed blastogenesis of mitogen-stimulated T lymphocytes. Am. J. Clin. Nutr. 54, 896-902. 

Soderberg, L.S.F., and Barnett, J.B. Exposure to inhaled isobutyl nitrite reduces T cell blastogenesis and antibody responsiveness. Fundam Appl Toxicol 17 821-824, 1991. 

Protease Inhibitors - Bestatin (56.), an aminopeptidase inhibitor isolated from Streptomyces olivoreticuli has been reported to stimulate cellular and humoral immunity against sheep red blood cells in micel53. Blastogenesis of peripheral lymphocytes from guinea pigs by concanavalin A and PHA was enhanced. 15, 155 Moreover, bestatin appeared to increase the effects of bleo-... 

Harris WR, Shifrine M. 1987. Inhibition of lymphocyte blastogenesis by serum leachates of fly ash. J Toxicol Environ Health 21 341-352. 

Pross SH, Klein TW, Newton C, Smith J, Widen R, Friedman H (1990) Age-related suppression of murine lymphoid ceU blastogenesis by marijuana components. Dev Comp Immunol 14 131-137... 

Hematologic Failure of stem-cell production decreased PMN chemotaxis decreased lymphocyte count with reduced helper T and increased suppressor T and killer cells decreased blastogenesis to phytohemagglutinin Anemia anergy decreased granuloma formation impaired response to chemotherapy increased infection rate... 

Discovery Pironetin (1) was isolated as a plant growth regulator that induces shortening of the plant height of rice [1,2] and as an immunosuppressor that inhibites the blastogenesis of both T and B cells [3]. 

T. Han and T. Ohnuma. The in vitro blastogenesis inhibited by Erwinia carotovora 1-asparaginase. Nature New Biol. 239 50 (1972). 

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