Isobutyl nitrite

Little is known regarding the pharmacokinetic properties of volatile nitrites in humans, particularly isobutyl nitrite and its primary metabolite, isobutyl alcohol. In rodents, after an intravenous infusion of isobutyl nitrite, blood concentrations peaked rapidly and then declined, with a half-life of 1.4 minutes and blood clearance rate of 2.9 L/min/kg (Kielbasa and Fung 2000). Approximately 98% of isobutyl nitrite is metabolized rapidly to isobutyl alcohol, concentrations of which also decline rapidly, with a half-life of 5.3 minutes. Bioavailability of inhaled isobutyl nitrite at a concentration of 300-900 ppm is estimated to be 43%. 

Schroeder HG Acute and delayed chloroform poisoning. Br J Anaeseth 37 972—975,1965 Schwartz AM The cause, relief and prevention of headaches arising from contact with dynamite. N Engl J Med 235 541-544, 1946 Schwartz RH, Peary P Abuse of isobutyl nitrite inhalation (rush) by adolescents. Clin Pediatr 25 308-310, 1986... 

Fig. 2.1 Commonly used organic nitrates and nitrites. GTN, glyceryl trinitrate ISDN, isosorbide dinitrate IAN, isoamyl nitrite IBN isobutyl nitrite.

Isobutyl nitrite [542-56-3] Sprague-Dawley rats LC5o(4-h) 2.89 Klonne et al., 1987a... 

Formation of chloroquinazolines by amine diazotization can also been performed, but in the case of 4-amino-2-chloro-5-iodo-6,7-dimethoxyquinazoline 122, chlorination with isobutyl nitrite and cupric chloride to give 123 was accompanied by hydrolysis to the analogous quinazolinone 124 <2005TL983>. 

SI sol in w and miscible with ale or eth. Can be prepd by treating isoamyl alcohol with a mixt of NaN02 +H2S04+H20 or by other methods(Ref 1). A detailed description of a lab procedure for the prepn of isobutyl nitrite is given in OrgSynth(Ref 3) and this method is suitable for the prepn of isoamyl nitrite Its QP is 812.64 keal/mol... 

The modified formulas, called butyl nitrite and isobutyl nitrite, did not require FDA approval because they were not marketed as either a drug or food product. They were marketed heavily in the gay community under the general name of poppers. By 1974, poppers were in full swing within the gay community, and large advertising campaigns were mounted in gay publications, according to Randy Viele, outreach coordinator for Project H.O.P.E. (HIV Outreach Prevention Education) in northeast New York. 

Insom-X see GBL GHB Invigorate see GBL GHB Ionamin see Diet pills Iophen DM NR see Dextromethorphan Ischott see Catha edulis Isobutyl nitrite see Inhalants Isocarboxazid Marplan see Antidepressants Isosorbide see Diuretics Iubulu see Catha edulis J La rocha see Rohypnol La salade see Catha edulis LA turnarounds see Dextroamphetamine Lady see Heroin Lady K see Ketamine Laevoamphetamine see Amphetamines Laudanum see Opium Laughing gas see Nitrous oxide LBJ see PCP (phencyclidine) Leaky bolla see PCP (phencyclidine) Leaky leak see PCP (phencyclidine) Lean (codeine cough syrup) see Codeine... 

Organic nitrites (amyl nitrite and isobutyl nitrite) cause dizziness, giddiness, rapid heart rate, lowered blood pressure, "speeding," and flushing of the skin. These effects last only a few minutes and can readily be repeated. The main effect of the drug on sexual performance is probably to enhance or prolong erection through the release of nitric oxide in the corpora cavernosa (see Chapter 19 Nitric Oxide, Donors, Inhibitors). 

Butyl Nitrite and Isobutyl Nitrite (Locker Room, Rush)... 

Butyl nitrite and isobutyl nitrite are close chemical relaiives of amyl nitrite that are not under any drug regulations. They are sold by mail tirder and over the counter in head sliops. They come in small bottles or aerosol cans with labels identilying them as liquid incense" or "room odorizer/ hut everyone wiio I uiys these products knows what they are for. Butyl nitrite and isobutyl nitrile are of recent appearance as recreational drugs Their effects are the same as those of poppers. 

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