Design scaffold

Drury JL, Mooney DJ (2003) Hydrogels for tissue engineering scaffold design variables and applications. Biomaterials 24 4337-4351... 

Fig. 5. (a) Schematic of the scaffold design showing the inner and outer scaffolds, (b and c) Inner scaffolds seeded with NSCs. (Scale bars 200 pm and 50 tm, respectively.) The outer section of the scaffold was created by means of a solid-liquid phase separation technique that produced long, axially oriented pores for axonal guidance as well as radial pores to allow fluid transport and inhibit the ingrowth of scar tissue (d scale bar, 100 pm), (e) Schematic of surgical insertion of the implant into the spinal cord. [Reproduced with permission from Teng et al. (2002).]... 

Enhancing tissue regeneration by controlling cell-scaffold interaction and the necessity to accommodate cellular metabolic demands through scaffold diffusivity were two fundamental scaffold-design requirements enunciated in the early 1990s (Cima et ah, 1991 Langer et ah, 1990). 

Flollister, S. J. (2009). Scaffold design and manufacturing From concept to clinic. Adv. Mater. 21, 3330-3342. 

Hollister SJ (2005) Porous scaffold design for tissue engineering. Nat Mater 4(7) 518-524... 

Migration and infiltration of cells into tissue engineering scaffolds are crucial factors for their success. Many types of scaffold design require that cells seeded in vitro or recruited in vivo are allowed to infiltrate and populate the scaffolds quickly. Microstructure has a significant effect on cell migration and infiltration, and understanding these effects may lead to better scaffold design. 

Turn mimetics, secondary structure mimetics that imitate turns when incorporated into peptides. Most secondary structure mimetics have been designed to imitate a /1-tum. Often, bicyclic heterocycles are employed as rigid scaffolds. The design, synthesis, and application of turn mimetics must cope with two problems (i) not aU scaffolds designed as /S-turn mimetics actually display the desired properties and... 

Apply biocompatible 2-D surface ligands to 3-D scaffold design... 

FIGURE 46.2 A functional surface based strategy to probe cell-ligand interactions — an iterative tissue engineering scaffold design approach. (Reproduced from Song, J. et al., /. Mater. Chem., 2004,14 2643-8. With permission.)... 

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